ChemicalBook > CAS DataBase List > ASP-9521

ASP-9521

Product Name
ASP-9521
CAS No.
1126084-37-4
Chemical Name
ASP-9521
Synonyms
ASP-9521;ASP-9521, >98%;17HSD5 inhibitor;AKR1C3 inhibitor;ASP 9521. AKR1C3 inhibitor;Inhibitor,inhibit,ASP-9521,ASP 9521;ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR;ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR;1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol;[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone
CBNumber
CB92731017
Molecular Formula
C19H26N2O3
Formula Weight
330.42
MOL File
1126084-37-4.mol
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ASP-9521 Property

Boiling point:
543.9±30.0 °C(Predicted)
Density 
1.183±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO:52.26(Max Conc. mg/mL);158.16(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);30.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.51(Max Conc. mM)
Ethanol:36.35(Max Conc. mg/mL);110.01(Max Conc. mM)
form 
A crystalline solid
pka
15.23±0.29(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27308
Product name
ASP9521
Packaging
10mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
27308
Product name
ASP9521
Packaging
25mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
27308
Product name
ASP9521
Packaging
5mg
Price
$62
Updated
2024/03/01
Tocris
Product number
6084
Product name
ASP9521
Purity
≥98%(HPLC)
Packaging
10
Price
$68
Updated
2021/12/16
Tocris
Product number
6084
Product name
ASP9521
Purity
≥98%(HPLC)
Packaging
50
Price
$284
Updated
2021/12/16
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ASP-9521 Chemical Properties,Usage,Production

Description

ASP9521 is an inhibitor of 17β-hydroxysteroid dehydrogenase type 5/aldo-keto reductase 1C3 (17β-HSD5/AKR1C3; IC50 = 120 nM). It is selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC50 = 20 μM). ASP9521 inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC50s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively). It inhibits androstenedione-dependent production of prostate specific androgen (PSA) in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3. ASP9521 (3 and 10 mg/kg) inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model.

Uses

ASP 9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). AKR1C3 is a promising therapeutic target in castration-resistant prostate cancer

ASP-9521 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASP-9521 Suppliers

China 48 India 1 United Kingdom 1 United States 10 Global 60
Shanghai Boyle Chemical Co., Ltd.
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Shanghai JiYi Biotechnology Co. Ltd.
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InvivoChem
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TargetMol Chemicals Inc.
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View Lastest Price from ASP-9521 manufacturers

Career Henan Chemica Co
Product
ASP-9521 1126084-37-4
Price
US $1.00/g
Min. Order
1g
Purity
Min98% HPLC/GC
Supply Ability
g/kg/ton Coreychem-Nicole
Release date
2020-11-06

1126084-37-4, ASP-9521Related Search:

6-Methoxyindole 3,4,5-Trimethoxybenzoyl chloride

  • ASP-9521
  • 1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol
  • AKR1C3 inhibitor
  • ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR
  • [4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone
  • 17HSD5 inhibitor
  • ASP 9521. AKR1C3 inhibitor
  • ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR
  • ASP-9521, >98%
  • Methanone, [4-(2-hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)-
  • (4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl)(5-methoxy-1H-indol-2-yl)methanone
  • Inhibitor,inhibit,ASP-9521,ASP 9521
  • 1126084-37-4