2,4,6-Trichlorophenyl forMate
- Product Name
- 2,4,6-Trichlorophenyl forMate
- CAS No.
- 4525-65-9
- Chemical Name
- 2,4,6-Trichlorophenyl forMate
- Synonyms
- 2,4,6-Trichlorophenyl forMate;Phenol, 2,4,6-trichloro-, 1-formate;Formic Acid 2,4,6-Trichlorophenyl Ester
- CBNumber
- CB92736784
- Molecular Formula
- C7H3Cl3O2
- Formula Weight
- 225.46
- MOL File
- 4525-65-9.mol
2,4,6-Trichlorophenyl forMate Property
- Melting point:
- 81.0 to 85.0 °C
- Boiling point:
- 281.2±40.0 °C(Predicted)
- Density
- 1.537±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Toluene
- form
- powder to crystal
- color
- White to Almost white
Safety
- HS Code
- 2915.13.1000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T3121
- Product name
- 2,4,6-Trichlorophenyl Formate
- Purity
- >97.0%(HPLC)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- T3121
- Product name
- 2,4,6-Trichlorophenyl Formate
- Purity
- >97.0%(HPLC)
- Packaging
- 5g
- Price
- $82
- Updated
- 2025/07/31
- Product number
- T900418
- Product name
- 2,4,6-Trichlorophenyl Formate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 5270AL
- Product name
- 2,4,6-Trichlorophenyl Formate
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- A119450
- Product name
- 2,4,6-Trichlorophenyl Formate
- Purity
- 95%
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
2,4,6-Trichlorophenyl forMate Chemical Properties,Usage,Production
Uses
2,4,6-Trichlorophenyl forMate is a highly active and readily available carbon monoxide (CO) substitute, primarily used in palladium-catalyzed carbonylation reactions, especially as an intermediate in the synthesis of chemicals such as pesticides, insecticides, and herbicides.
Synthesis
64-18-6
88-06-2
4525-65-9
1. In a dry reaction flask, formic acid (57.3 mL, 1519 mmol) and acetic anhydride (115 mL, 1216 mmol) were added, stirred and heated to 60 °C, and the reaction was maintained at this temperature for 1.5 hours. 2. Upon completion of the reaction, the reaction mixture was cooled to room temperature. 3. The cooled reaction solution was slowly poured into a flask containing 2,4,6-trichlorophenol (30 g, 152 mmol) and sodium acetate (12.46 g, 152 mmol). 4. The mixture was stirred and reacted at room temperature for 3.5 hours. 5. At the end of the reaction, the reaction mixture was diluted with toluene (300 mL) followed by washing the organic phase with deionized water (2 x 200 mL). 6. The organic phase was separated, dried over anhydrous sodium sulfate and filtered to remove the desiccant. 7. The filtrate was concentrated to dryness under reduced pressure to give white needle-like crystals of 2,4,6-trichlorophenyl formate (32.45 g). 8. The product was analyzed by liquid chromatography. 8. The product was analyzed and confirmed by liquid chromatography-mass spectrometry (LCMS) using 2 mM formic acid as the mobile phase with a retention time (Rt) of 1.15 min. The [M + Na]+ peak was observed by mass spectrometry at m/z of 249.8.
References
[1] Organic Letters, 2012, vol. 14, # 20, p. 5370 - 5373,4
[2] ChemCatChem, 2016, vol. 8, # 10, p. 1788 - 1791
[3] Recueil des Travaux Chimiques des Pays-Bas, 1965, vol. 84, p. 1247 - 1252
[4] Patent: WO2017/37116, 2017, A1. Location in patent: Page/Page column 76
[5] Patent: WO2017/50714, 2017, A1. Location in patent: Page/Page column 53
2,4,6-Trichlorophenyl forMate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4,6-Trichlorophenyl forMate manufacturers
- Product
- 246-Trichlorophenyl forMate 4525-65-9
- Price
- US $25.00-11.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-08-12