N-(chloracetyl)methanesulfonamide
- Product Name
- N-(chloracetyl)methanesulfonamide
- CAS No.
- 202658-88-6
- Chemical Name
- N-(chloracetyl)methanesulfonamide
- Synonyms
- Selexipag Impurity 40;N-(chloracetyl)methanesulfonamide;2-chloro-N-(methylsulfonyl)-Acetamide;Acetamide, 2-chloro-N-(methylsulfonyl)-
- CBNumber
- CB92738425
- Molecular Formula
- C3H6ClNO3S
- Formula Weight
- 171.6
- MOL File
- 202658-88-6.mol
N-(chloracetyl)methanesulfonamide Property
- Melting point:
- 114 - 116°C
- Density
- 1.474±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.43±0.40(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C3H6ClNO3S/c1-9(7,8)5-3(6)2-4/h2H2,1H3,(H,5,6)
- InChIKey
- BKLFBPWLPOUGTM-UHFFFAOYSA-N
- SMILES
- C(NS(C)(=O)=O)(=O)CCl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C373720
- Product name
- 2-Chloro-N-(methylsulfonyl)acetamide
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- A375774
- Product name
- 2-Chloro-N-(methylsulfonyl)acetamide
- Purity
- 97%
- Packaging
- 100mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- A375774
- Product name
- 2-Chloro-N-(methylsulfonyl)acetamide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $14
- Updated
- 2021/12/16
- Product number
- A375774
- Product name
- 2-Chloro-N-(methylsulfonyl)acetamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- A375774
- Product name
- 2-Chloro-N-(methylsulfonyl)acetamide
- Purity
- 97%
- Packaging
- 5g
- Price
- $86
- Updated
- 2021/12/16
N-(chloracetyl)methanesulfonamide Chemical Properties,Usage,Production
Uses
2-Chloro-N-(methylsulfonyl)acetamide acts as a reagent for the preparation of piperazinylquinolonecarboxamides as antivirals. Solid phase preparation of peptidines, glycine-amidine-based oligomers.
Synthesis
3144-09-0
79-04-9
202658-88-6
To a 2-liter three-necked flask was added 1 liter of ethyl acetate and 66 g (0.69 mol) of methanesulfonamide and dissolved with stirring. Under cooling in an ice bath, 109 g (0.77 mol) of chloroacetyl chloride was slowly added dropwise, with the rate of the drop being controlled to maintain the reaction temperature at no more than 65 °C. The reaction temperature was then increased to 65 °C. The reaction temperature was then increased to 65 °C. After the dropwise addition, the ice bath was withdrawn, the temperature was gradually increased to 65 °C and the reaction was stirred at this temperature for 12 h. The reaction progress was monitored by TLC. After completion of the reaction, the reaction mixture was slowly cooled to 0 °C and a large amount of white solid was precipitated. The solid was collected by filtration, washed with cold ethyl acetate and dried under vacuum to afford 112 g of 2-chloro-N-(methylsulfonyl)acetamide (SLP-10b, X = Cl) in 94% yield. Product characterization: 1H NMR (400 MHz, CDCl3) δ: 4.02 (s, 2H), 3.28 (s, 3H); ESI/MS m/z: 171 [M+H]+.
storage
Inert atmosphere,Store in freezer, under -20℃.
References
N-(chloracetyl)methanesulfonamide is prepared by the reaction of methanesulfonamide and chloroacetyl chloride. The specific synthesis steps are as follows:
In a 2-liter reaction flask, 1 liter of ethyl acetate and 66 grams of methylsulfonamide were added, and 109 grams of chloroacetyl chloride was gradually added; the temperature was gradually increased to 65C for 12 hours until the end of the reaction.The reaction solution gradually cooled to 0 degree, and a large amount of white solid precipitated; it was filtered and dried to obtain 112 g of solid SLP-10b (X=Cl).Yield: 94%.H NMR (400MHz, CDCl3): delta 4.02 (s, 2H), 3.28s, 3H)ESI/MS+(m/z):171.
N-(chloracetyl)methanesulfonamide Preparation Products And Raw materials
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View Lastest Price from N-(chloracetyl)methanesulfonamide manufacturers
- Product
- N-(chloracetyl)methanesulfonamide 202658-88-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08