Altiratinib

Product Name: Altiratinib
CAS No.: 1345847-93-9
Chemical Name: Altiratinib
Synonyms: CS-1690;DP 5164;DCC-2701;Altiratinib;Altiratinib, >98%;Altiratinib(DCC2701);DCC2701 (Altiratinib);Altiratinib(DCC-22701);Altiratinib(DCC2701,DP5164);ALTIRATINIB; DCC2701;DCC 2701
CBNumber: CB92742653
Molecular Formula: C26H21F3N4O4
Formula Weight: 510.46
MOL File: 1345847-93-9.mol

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Altiratinib Property

Boiling point:: 763.5±60.0 °C(Predicted)
Density: 1.557±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥21.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 12.09±0.70(Predicted)
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18777
Product name: Altiratinib
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18777
Product name: Altiratinib
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 18777
Product name: Altiratinib
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 18777
Product name: Altiratinib
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Usbiological

Product number: 474056
Product name: Altiratinib
Packaging: 100mg
Price: $1296
Updated: 2021/12/16

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Altiratinib Chemical Properties,Usage,Production

Biological Activity

altiratinib (dcc-2701) is a potent inhibitor of c-met/tie-2/vegfr with ic50 values of 2.7, 8.0 and 9.2 nm, respectively [1].hepatocyte growth factor receptor (c-met) is a tyrosine kinase receptor for hepatocyte growth factor and is essential for wound healing and embryonic development. tek tyrosine kinase (tie-2) is a receptor for angiopoietin-1 (ang-1) and is important for endothelial cell-smooth muscle cell communication. vegfr is a tyrosine kinase receptor for vascular endothelial growth factor that involved in both vasculogenesis and angiogenesis.altiratinib (dcc-2701) is a potent c-met/tie-2/vegfr inhibitor. altiratinib potently inhibited met kinase and activating oncogenic met mutations and also inhibited trka, trkb and trkc kinases with ic50 values of 0.85, 4.6, and 0.83 nm, respectively. in ebc-1 nsclc and mkn-45 gastric cancer cell lines overexpressing met, altiratinib inhibited met phosphorylation with ic50 values of 0.85 and 2.2 nm, respectively. in vegf-stimulated huvecs, altiratinib inhibited vegfr2 phosphorylation with ic50 value of 4.7 nm. in huvecs and ea.hy926 cells, altiratinib inhibited tie2 phosphorylation stimulated by ang-1 with ic50 values of 1.0 and 2.6 nm, respectively [1].in the met-amplified mkn-45 xenograft model, altiratinib (30 mg/kg) inhibited met phosphorylation by >95% for the 24-hour period [1]. in nude mouse xenografted skov3 cells, dcc-2701 (10 or 20 mg/kg for 28 days) significantly reduced tumor burden by 53% and 52%, respectively [2].

References

[1]. smith bd, kaufman md, leary cb, et al. altiratinib inhibits tumor growth, invasion, angiogenesis, and microenvironment-mediated drug resistance via balanced inhibition of met, tie2, and vegfr2. mol cancer ther, 2015.
[2]. kwon y, smith bd, zhou y, et al. effective inhibition of c-met-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment. oncogene, 2015, 34(2): 144-153.

Altiratinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Altiratinib Suppliers

China 89 India 1 United States 12 Global 102

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

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Country: United States
ProdList: 6251
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Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
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Combi-Blocks Inc.

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Country: United States
ProdList: 6618
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View Lastest Price from Altiratinib manufacturers

Career Henan Chemical Co

Product: Altiratinib 1345847-93-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

1345847-93-9, AltiratinibRelated Search:

N-(4-(2-(cyclopropanecarboxamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Altiratinib(DCC2701)

Altiratinib

DP 5164

DCC2701 (Altiratinib)

Altiratinib(DCC-22701)

Altiratinib(DCC2701,DP5164)

DCC-2701

ALTIRATINIB; DCC2701;DCC 2701;DCC-2701

ALTIRATINIB; DCC2701;DCC 2701

CS-1690

Altiratinib, >98%

1,1-Cyclopropanedicarboxamide, N-[4-[[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-2,5-difluorophenyl]-N'-(4-fluorophenyl)-

N-[4-[[2-[(Cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-2,5-difluorophenyl]-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

1345847-93-9

345847-93-9

C26H21F3N4O4

Inhibitors