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Aminolevulinic acid phosphate

Product Name
Aminolevulinic acid phosphate
CAS No.
868074-65-1
Chemical Name
Aminolevulinic acid phosphate
Synonyms
5-Aminolevulinic acid phosphate;Aminolevulinic acid phosphate;5-Aminolevulinic acid (phosphote);5-Aminolevulinic acid phosphate（ALA ）;5-Amino-4-oxopentanoic acid phosphate;5-Aminolevulinic Acid Phosphate (5-ALA);5-amino-4-oxopentanoic acid,phosphoric acid;ALA Synonyms：5-Aminolevulinic acid phosphate;Pentanoic acid, 5-amino-4-oxo-, phosphate (1:1);5-aminolevulinic acid phosphate,5-ALA phosphate
CBNumber
CB92744516
Molecular Formula
C5H12NO7P
Formula Weight
229.125041
MOL File
868074-65-1.mol
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Aminolevulinic acid phosphate Property

InChI
InChI=1S/C5H9NO3.H3O4P/c6-3-4(7)1-2-5(8)9;1-5(2,3)4/h1-3,6H2,(H,8,9);(H3,1,2,3,4)
InChIKey
XWNWBYZHOAIHTK-UHFFFAOYSA-N
SMILES
C(O)(=O)CCC(=O)CN.P(O)(O)(O)=O
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Hazard and Precautionary Statements (GHS)

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Aminolevulinic acid phosphate Chemical Properties,Usage,Production

Description

Aminolevulinic acid phosphate is a topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX), a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect.

Biological Functions

Aminolevulinic acid phosphate (5-ALA) is one of the natural amino acids. It is not involved in protein synthesis but is finally metabolized to heme, which composes catalase, cytochrome, or hemoglobin as a cofactor. Externally supplied 5-ALA is imported inside the cell via peptide transporter 1, which is expressed on the cell membrane and mitochondria; similar to the naturally synthesized one, it is converted to coproporphyrinogen III and then protoporphyrin IX (PPIX) and further metabolized to heme in the presence of the ferrous ions provided from the mitochondria or supplemented sodium ferrous citrate (SFC). SFC provides ferrous ions essential for 5-ALA metabolism into heme caused by ferrochelatase. Heme is metabolized to biliverdin and carbon monoxide by heme oxygenase-1 (HO-1), and biliverdin is degraded to bilirubin. Without sufficient ferrous ions, PPIX is not further converted but exported outside the cell by an ATP-binding cassette G (ABCG) transporter. In contrast, a portion of PPIX accumulates in the cell. Recently, in vitro, antiviral effects of 5-ALA against feline infectious peritonitis virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were reported, although its antiviral mechanism has not been elucidated yet[1].

storage

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

References

[1] Shizuka Hirose. “Antiviral Effects of 5-Aminolevulinic Acid Phosphate against Classical Swine Fever Virus: In Vitro and In Vivo Evaluation.” Pathogens (2022).

Aminolevulinic acid phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Aminolevulinic acid phosphate manufacturers

Sinoway Industrial co., ltd.
Product
5-Aminolevulinic acid phosphate 868074-65-1
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
98% hplc，
Supply Ability
20 tons
Release date
2021-08-11
SUZHOU NMT BIOTECH CO.,LTD
Product
Aminolevulinic acid phosphate 868074-65-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20 tons
Release date
2024-10-11
Hebei Yanxi Chemical Co., Ltd.
Product
5-amino-4-oxopentanoic acid,phosphoric acid 868074-65-1
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-12

868074-65-1, Aminolevulinic acid phosphateRelated Search:


  • 5-amino-4-oxopentanoic acid,phosphoric acid
  • 5-aminolevulinic acid phosphate,5-ALA phosphate
  • 5-Aminolevulinic acid phosphate
  • 5-Amino-4-oxopentanoic acid phosphate
  • 5-Aminolevulinic acid phosphate（ALA ）
  • Pentanoic acid, 5-amino-4-oxo-, phosphate (1:1)
  • ALA Synonyms：5-Aminolevulinic acid phosphate
  • 5-Aminolevulinic Acid Phosphate (5-ALA)
  • Aminolevulinic acid phosphate
  • 5-Aminolevulinic acid (phosphote)
  • 868074-65-1
  • API
  • 868074-65-1