ChemicalBook > CAS DataBase List > MS417
MS417
- Product Name
- MS417
- CAS No.
- 916489-36-6
- Chemical Name
- MS417
- Synonyms
- MS147;MS417;GTPL7512;MS-417; M S417;MS417（GTPL7512）;methyl(S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-methyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;Epigenetic Reader Domain,inhibit,MS417,HIV,MS 417,GTPL 7512,Inhibitor,MS-417,GTPL-7512,Human immunodeficiency virus;methyl 2-((6S,Z)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, methyl ester, (6S)-
- CBNumber
- CB92748943
- Molecular Formula
- C20H19ClN4O2S
- Formula Weight
- 414.91
- MOL File
- 916489-36-6.mol
More
Less
MS417 Property
- Boiling point:
- 596.8±60.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Ethanol : 50 mg/mL (120.51 mM)
- form
- Solid
- pka
- 1.86±0.60(Predicted)
- color
- Light yellow to yellow
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2442
- Product name
- MS417
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $152
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML2442
- Product name
- MS417
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $396
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0034388
- Product name
- MS417
- Purity
- 99.51%
- Packaging
- 50mg
- Price
- $420
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0034388
- Product name
- MS417
- Purity
- 99.51%
- Packaging
- 100mg
- Price
- $700
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0034388
- Product name
- MS417
- Purity
- 99.51%
- Packaging
- 250mg
- Price
- $1300
- Updated
- 2021/12/16
More
Less
MS417 Chemical Properties,Usage,Production
Definition
ChEBI: MS-417 is a member of the class of thienotriazolodiazepines that is the methyl ester of [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid. A bromodomain and extra-terminal domain (BET)-specific inhibitor that belongs to a group of thienodiazepine-based compounds It is a thienotriazolodiazepine, a member of monochlorobenzenes and a methyl ester. It is an enantiomer of a MS-566.
Biological Activity
MS417, a (+)-JQ1 analog, is a potent inhibitor of bromodomain-containing protein 4 (BRD4) th at is highly specific for BRD4-BD1 and BRD4-BD2. MS417 binds with similar affinity to BRD4-BD1 and BRD4-BD2 (Kd =36.1, and 25.4 nM), while bulky tBu of JQ1 prevents tight binding to the cavity at BD1.
MS417 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
MS417 Suppliers
- Tel
- 13816107857
- Fax
- qq: 276312098
- sales@fortunechem-sh.com
- Country
- China
- ProdList
- 796
- Advantage
- 58
- Tel
- 18051538752
- 3755454181@qq.com
- Country
- China
- ProdList
- 438
- Advantage
- 55
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4586
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8010
- Advantage
- 62
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 0550-5196001 15000891977
- Fax
- 0550-5196001
- wj520wjxby@126.com
- Country
- China
- ProdList
- 1927
- Advantage
- 55
- Tel
- 021-021-00000000 18221039705
- Fax
- QQ:17263424
- finetechpharm@126.com
- Country
- China
- ProdList
- 208
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32159
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58