5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole

Product Name: 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole
CAS No.: 1222810-74-3
Chemical Name: 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole
Synonyms: VU591;VU591 >=98% (HPLC);VU591, 10 mM in DMSO;K _ir1.1 Inhibitor, VU591;2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole);2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole);1H-Benzimidazole, 2,2'-[oxybis(methylene)]bis[6-nitro-;2,2'-(Oxybis(methylene))bis(5-nitro-1H-benzo[d]imidazole);2,2-(Oxydimethanediyl)Bis(5-Nitro-1H-Benzimidazole)(WXC03621);6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole
CBNumber: CB92750652
Molecular Formula: C16H12N6O5
Formula Weight: 368.3
MOL File: 1222810-74-3.mol

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5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole Property

Boiling point:: 777.9±55.0 °C(Predicted)
Density: 1.641±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥12mg/mL
pka: 7.88±0.30(Predicted)
form: powder
color: white to tan
InChI: 1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)
InChIKey: ZQPXNYLXYNRFNP-UHFFFAOYSA-N
SMILES: [O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1

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Safety

WGK Germany: 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0077
Product name: VU591
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $113
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0077
Product name: VU591
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $451
Updated: 2025/07/31

TRC

Product number: N901035
Product name: 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole
Packaging: 10mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-0035884
Product name: VU591
Purity: 99.38%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0035884
Product name: VU591
Purity: 99.38%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole Chemical Properties,Usage,Production

Uses

VU591 may be used in cell signaling studies.

Biological Activity

VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) th at is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.

in vivo

VU591 (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST^[2].

Animal Model:	Male ICR mice^[2]
Dosage:	1.842 μg
Administration:	i.c.v.; 1.842 μg;
Result:	Showed antidepressive effect in the tail suspension test (TST).

5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole Suppliers

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1222810-74-3, 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazoleRelated Search:

2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole)

2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole)

5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole

VU591

6-NITRO-2-[(6-NITRO-1H-BENZIMIDAZOL-2-YL)METHOXYMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE

2,2-(Oxydimethanediyl)Bis(5-Nitro-1H-Benzimidazole)(WXC03621)

2,2'-(Oxybis(methylene))bis(5-nitro-1H-benzo[d]imidazole)

1H-Benzimidazole, 2,2'-[oxybis(methylene)]bis[6-nitro-

VU591 >=98% (HPLC)

6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole

neurological,inhibit,Kir1.1,VU 591,VU591,Inhibitor,VU-591,ROMK channel,KcsA,Potassium Channel,ROMK Inhibitor

VU591, 10 mM in DMSO

K <sub>ir</sub>1.1 Inhibitor, VU591

1222810-74-3