10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine

Product Name: 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
CAS No.: 55476-47-6
Chemical Name: 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
Synonyms: PSB-12062;PSB-12062 >=98% (HPLC);PSB-12062, 10 mM in DMSO;10-Tosyl-10H-phenoxazine;N-(p-Methylphenylsulfonyl)phenoxazine;10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine;10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]-;P2X Receptor,Inhibitor,PSB12062,PSB 12062,PSB-12062,P2XRs,inhibit
CBNumber: CB92751073
Molecular Formula: C19H15NO3S
Formula Weight: 337.39
MOL File: 55476-47-6.mol

More

Less

10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine Property

storage temp.: 2-8°C
solubility: DMSO: soluble2mg/mL, clear (warmed)
form: powder
color: white to beige

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0753
Product name: PSB-12062
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $119
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0753
Product name: PSB-12062
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $375
Updated: 2024/03/01

AK Scientific

Product number: SYN5424
Product name: PSB-12062
Packaging: 50mg
Price: $406
Updated: 2021/12/16

ChemScene

Product number: CS-6918
Product name: PSB-12062
Purity: 99.06%
Packaging: 25mg
Price: $198
Updated: 2021/12/16

ChemScene

Product number: CS-6918
Product name: PSB-12062
Purity: 99.06%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

More

Less

10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine Chemical Properties,Usage,Production

Uses

PSB-12062 has been used as a P2X4 antagonist to pre-tre at macrophages in inhibitor screening studies to understand the inflammation process. It has also been used as P2X4 antagonists to pre-tre at P2X7-deficient BV-2 cells to elucidate the roles of P2X4.

Biological Activity

PSB-12062 is a potent and selective P2X4 antagonist with IC50 value of 1.38 μM for human P2X4.

in vitro

10-Tosyl-10H-phenoxazine shows similar potency in human, rat, and mouse species.It shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However,it is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM).

target

IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)

10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine Suppliers

China 35 United States 5 Global 40

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4569
Advantage: 55

Zhengzhou Guancheng Laboratory equipment Sales

Tel: 0371-88888888 272369594
Fax: QQ:272369594
Email: 2723695949@qq.com
Country: China
ProdList: 4995
Advantage: 50

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9805
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2951
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7312
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6037 18920794737
Email: sales@heowns.com
Country: China
ProdList: 23083
Advantage: 60

Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 15502154572
Fax: -
Email: yuben012@sina.com
Country: China
ProdList: 506
Advantage: 58

Amel Pharmatech Corporation

Tel: 888-4366503
Fax: 888-502-1736
Email: sales@amelpharmatech.com
Country: China
ProdList: 5586
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10524
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3021
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 10000
Advantage: 58

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 2973
Advantage: 58

Nanjing Bic Biotechnology Co., Ltd

Tel: 025-58906079 17352406906
Email: sales@bicbiotech.com
Country: China
ProdList: 7996
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 13823398779 18670069958
Email: 3062105966@qq.com
Country: China
ProdList: 3343
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9266
Advantage: 58

Tel
Email: sangon@qq.com
Country: CHINA
ProdList: 47239
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +86-18621343501; +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33338
Advantage: 58

Nantong HI-FUTURE Biology Co., Ltd.

Tel: +undefined18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3135
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6705
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Qiming Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6502
Advantage: 58

Jiangxi Jianglan Pure Biological Reagent Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6134
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6748
Advantage: 58

Shanghai Wowu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shhebio@126.com
Country: CHINA
ProdList: 6137
Advantage: 58

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

55476-47-6, 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazineRelated Search:

3-Phenylpyruvic acid Sarcosine (Methoxymethyl)triphenylphosphonium chloride Chlorophenyl

10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine

PSB-12062

10-Tosyl-10H-phenoxazine

N-(p-Methylphenylsulfonyl)phenoxazine

10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]-

PSB-12062 >=98% (HPLC)

P2X Receptor,Inhibitor,PSB12062,PSB 12062,PSB-12062,P2XRs,inhibit

PSB-12062, 10 mM in DMSO

55476-47-6