ChemicalBook > CAS DataBase List > 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide

2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide

Product Name
2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide
CAS No.
1414469-59-2
Chemical Name
2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide
Synonyms
TAE-1;TAE-1 >=98% (HPLC);β-amyloid peptide,inhibit,Cholinesterase (ChE),TAE1,Amyloid-β,TAE-1,Abeta,Inhibitor,TAE 1;2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide;2,2',2"-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1- phenylenecarbonyloxy)]tris[N,N,N-trimethyl- ethanaminium] triiodid;2,2',2'-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethylethanaminium] iodide (1:3);2,2',2''-((4,4',4''-((1,3,5-Triazine-2,4,6-triyl)tris(oxy))tris(benzoyl))tris(oxy))tris(N,N,N-trimethylethan-1-aminium) iodide
CBNumber
CB92751088
Molecular Formula
C39H51I3N6O9
Formula Weight
1128.57045
MOL File
1414469-59-2.mol
More
Less

2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Property

storage temp. 
2-8°C
solubility 
H2O: soluble5mg/mL, clear (warmed)
form 
powder
color 
white to beige
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
20464
Product name
TAE-1
Packaging
5mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
20464
Product name
TAE-1
Packaging
1mg
Price
$28
Updated
2023/01/06
Cayman Chemical
Product number
20464
Product name
TAE-1
Packaging
10mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
20464
Product name
TAE-1
Packaging
25mg
Price
$81
Updated
2024/03/01
TRC
Product number
T460315
Product name
TAE-1
Packaging
5mg
Price
$285
Updated
2021/12/16
More
Less

2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Chemical Properties,Usage,Production

Biological Activity

tae-1 is an inhibitor of amyloid-β fibril formation and aggregation.alzheimer’s disease (ad), a progressive neurodegenerative disorder, is characterized by the cerebral accumulation of insoluble aggregates of amyloid-β peptides (aβ). although the precise mechanisms governing neuronal loss remains ambiguous, toxicity resulting from aβ-activated pathways is evident.

in vitro

in a previous study, the authors examined the effects of tae-1 on differentiated human sh-sy5y neuronal cells grown in tissue culture. results showed that the stimulation of neuronal cellular process length and branching was noted. moreover, the increased synaptophysin suggested that tae-1 could stimulate synapse formation. increased expression of map2 was also observed, indicating that tae-1 promoted the differentiation of human neurons. in addition, targeted ache inhibition was evaluated by electrochemical quantification of the enzymatic product, thiocholine, on unmodified gold screen-printed electrodes. it was found that at increasing tae-1concentrations, there was a corresponding decrease in the ache activity resulting in reduced amount of oxidizable thiocholine. the ic50 value was found to be 0.465 μm for tae-1 [1].

IC 50

0.3 ± 0.02 μm for ache; 3.9 ± 0.2 μm for buche

References

[1] veloso aj, chow am, dhar d, tang dw, ganesh hv, mikhaylichenko s, brown ir, kerman k. biological activity of sym-triazines with acetylcholine-like substitutions as multitarget modulators of alzheimer's disease. acs chem neurosci. 2013 jun 19;4(6):924-9.

2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Suppliers

Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2992
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30240
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3600
Advantage
58
Jinan ponder chemical co. LTD
Tel
0531-0000
Email
thinklifescience@163.com
Country
China
ProdList
19689
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
Tel
15317229551
Fax
QQ:3607245178
Email
15151849396@163.com
Country
China
ProdList
994
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
3991
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44808
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7973
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8617
Advantage
58
Wuhan Augda Biotechnology Co., Ltd
Tel
15071299552
Fax
QQ:262933239
Email
262933239@qq.com
Country
China
ProdList
6883
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62163
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel
024-024-88590548 18341751992
Email
757984502@qq.com
Country
China
ProdList
891
Advantage
58
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
5797
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4871
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
6813
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29977
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12005
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
ZhengZhou Edward Biology Co.,Ltd
Tel
13298105281 13298105281
Email
1522334715@qq.com
Country
China
ProdList
7508
Advantage
58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
Tel
17316404525
Email
209533805@qq.com
Country
China
ProdList
9762
Advantage
58
Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel
+8613720134139
Email
orders@jknbiochem.com
Country
China
ProdList
5221
Advantage
58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel
+86-18341751992 +86-15382112998
Email
757984502@qq.com
Country
China
ProdList
892
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8467
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Beijing Dongge Boye Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1861586486@qq.com
Country
CHINA
ProdList
6648
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
info@f-biology.com
Country
CHINA
ProdList
6025
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6158
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6654
Advantage
58
Morning Student Science and Technology (Guangzhou) Co., Ltd.
Tel
--
Fax
--
Email
chenxue_gz@163.com
Country
CHINA
ProdList
6600
Advantage
58

1414469-59-2, 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodideRelated Search:


  • 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide
  • TAE-1
  • TAE-1 >=98% (HPLC)
  • 2,2',2"-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1- phenylenecarbonyloxy)]tris[N,N,N-trimethyl- ethanaminium] triiodid
  • 2,2',2'-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethylethanaminium] iodide (1:3)
  • β-amyloid peptide,inhibit,Cholinesterase (ChE),TAE1,Amyloid-β,TAE-1,Abeta,Inhibitor,TAE 1
  • 2,2',2''-((4,4',4''-((1,3,5-Triazine-2,4,6-triyl)tris(oxy))tris(benzoyl))tris(oxy))tris(N,N,N-trimethylethan-1-aminium) iodide
  • 1414469-59-2
  • C39H51N6O93I