2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide

ChemicalBook > CAS DataBase List > 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide

2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide

Product Name: 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide
CAS No.: 1414469-59-2
Chemical Name: 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide
Synonyms: TAE-1;TAE-1 >=98% (HPLC);β-amyloid peptide,inhibit,Cholinesterase (ChE),TAE1,Amyloid-β,TAE-1,Abeta,Inhibitor,TAE 1;2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide;2,2',2"-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1- phenylenecarbonyloxy)]tris[N,N,N-trimethyl- ethanaminium] triiodid;2,2',2'-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethylethanaminium] iodide (1:3);2,2',2''-((4,4',4''-((1,3,5-Triazine-2,4,6-triyl)tris(oxy))tris(benzoyl))tris(oxy))tris(N,N,N-trimethylethan-1-aminium) iodide
CBNumber: CB92751088
Molecular Formula: C39H51I3N6O9
Formula Weight: 1128.57045
MOL File: 1414469-59-2.mol

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2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Property

storage temp.: 2-8°C
solubility: H2O: soluble5mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20464
Product name: TAE-1
Packaging: 5mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 20464
Product name: TAE-1
Packaging: 1mg
Price: $28
Updated: 2023/01/06

Cayman Chemical

Product number: 20464
Product name: TAE-1
Packaging: 10mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 20464
Product name: TAE-1
Packaging: 25mg
Price: $81
Updated: 2024/03/01

TRC

Product number: T460315
Product name: TAE-1
Packaging: 5mg
Price: $285
Updated: 2021/12/16

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2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Chemical Properties,Usage,Production

Biological Activity

tae-1 is an inhibitor of amyloid-β fibril formation and aggregation.alzheimer’s disease (ad), a progressive neurodegenerative disorder, is characterized by the cerebral accumulation of insoluble aggregates of amyloid-β peptides (aβ). although the precise mechanisms governing neuronal loss remains ambiguous, toxicity resulting from aβ-activated pathways is evident.

in vitro

in a previous study, the authors examined the effects of tae-1 on differentiated human sh-sy5y neuronal cells grown in tissue culture. results showed that the stimulation of neuronal cellular process length and branching was noted. moreover, the increased synaptophysin suggested that tae-1 could stimulate synapse formation. increased expression of map2 was also observed, indicating that tae-1 promoted the differentiation of human neurons. in addition, targeted ache inhibition was evaluated by electrochemical quantification of the enzymatic product, thiocholine, on unmodified gold screen-printed electrodes. it was found that at increasing tae-1concentrations, there was a corresponding decrease in the ache activity resulting in reduced amount of oxidizable thiocholine. the ic50 value was found to be 0.465 μm for tae-1 [1].

IC 50

0.3 ± 0.02 μm for ache; 3.9 ± 0.2 μm for buche

References

[1] veloso aj, chow am, dhar d, tang dw, ganesh hv, mikhaylichenko s, brown ir, kerman k. biological activity of sym-triazines with acetylcholine-like substitutions as multitarget modulators of alzheimer's disease. acs chem neurosci. 2013 jun 19;4(6):924-9.

2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide Preparation Products And Raw materials

Raw materials

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1414469-59-2, 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodideRelated Search:

2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide

TAE-1

TAE-1 >=98% (HPLC)

2,2',2"-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1- phenylenecarbonyloxy)]tris[N,N,N-trimethyl- ethanaminium] triiodid

2,2',2'-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethylethanaminium] iodide (1:3)

β-amyloid peptide,inhibit,Cholinesterase (ChE),TAE1,Amyloid-β,TAE-1,Abeta,Inhibitor,TAE 1

2,2',2''-((4,4',4''-((1,3,5-Triazine-2,4,6-triyl)tris(oxy))tris(benzoyl))tris(oxy))tris(N,N,N-trimethylethan-1-aminium) iodide

1414469-59-2

C39H51N6O93I