ONO-4059

Product Name: ONO-4059
CAS No.: 1351635-67-0
Chemical Name: ONO-4059
Synonyms: CS-1629;GS-4059;ONO-4059;ON 0459 analog;ON-0459 analog;GS-4059 analog;ONO-4059 (analog);ONO-4059 analogue;ONO-4059 (ONO-WG-307);ON 0459 ANALOG;ON-0459 ANALOG
CBNumber: CB92756513
Molecular Formula: C25H24N6O3
Formula Weight: 456.5
MOL File: 1351635-67-0.mol

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ONO-4059 Property

Boiling point:: 714.0±70.0 °C(Predicted)
Density: 1.364±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 3.15±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18924
Product name: ONO-4059 analog
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18924
Product name: ONO-4059 analog
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 18924
Product name: ONO-4059 analog
Purity: ≥98%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 18924
Product name: ONO-4059 analog
Purity: ≥98%
Packaging: 25mg
Price: $479
Updated: 2024/03/01

ApexBio Technology

Product number: B5941
Product name: ONO-4059
Packaging: 25mg
Price: $504
Updated: 2021/12/16

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ONO-4059 Chemical Properties,Usage,Production

Description

ONO-4059 analog is a derivative of the Bruton’s tyrosine kinase (BTK) inhibitor ONO-4059 .

in vitro

ono-4059 inhibited the tmd-8 cell growth and btk phosphorylation in a concentration-dependent manner. furthermore, the decrease in btk phosphorylation subsequently down-regulated erk phosphorylation. after the combination of ono-4059 with doxorubicin, etoposide, vincristine and dexamethasone, increased apoptosis ratio was observed, 25, 20, 17 and 29%, respectively [1].

in vivo

for the 100-200 mm3 tumour groups, tumour growth inhibition at the final treatment day was 23% in qd, 72.9% in bd and 100% in dose mixed in food, groups respectively. for the 400-450 mm3 tumour groups, no growth inhibition was observed in the qd group and, growth inhibitions of 27.5% in bd and 100% in dose mixed in food were observed. the pk concentration and phosphorylated btk inhibition levels of those animals whose dose was mixed in with food were higher than that of other treatment groups [2].

IC 50

2.2 nm for btk kinase activity

References

[1] tomoko yasuhiro, toshio yoshizawa, joseph tp birkett, and kazuhito kawabata. ono-4059, a novel bruton’s tyrosine kinase (btk) inhibitor: synergistic activity in combination with chemotherapy in a abc-dlbcl cell line. 2013; blood: 122 (21): 5151 - 5151
[2] toshio yoshizawa, tomoko yasuhiro, hideyuki honda, and kazuhito kawabata. ono-4059—a potent and selective reversible bruton’s tyrosine kinase (btk) inhibitor: single agent, twice daily (bd) dosing and dosing with food results in sustained, high trough levels of ono-4059, translating into 100% tumour remission in a tmd-8 xenograft model. 2014; blood: 124 (21) 4502 - 4502
[3] simon rule, nimish shah, gilles andre salles et al. a phase i study of the oral btk inhibitor ono-4059 in patients with relapsed/refractory b-cell lymphoma. blood. 2013 122 (21): 4397 – 4397.

ONO-4059 Preparation Products And Raw materials

Raw materials

Preparation Products

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ONO-4059 Suppliers

China 73 India 1 United States 9 Global 83

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
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Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Advantage: 61

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
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TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
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CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
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AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
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View Lastest Price from ONO-4059 manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: ONO-4059 (analog) 1351635-67-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: ONO-4059 (analog) 1351635-67-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

Career Henan Chemical Co

Product: ONO-4059 1351635-67-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

1351635-67-0, ONO-4059Related Search:

6-AMINO-7-(4-PHENOXYPHENYL)-9-[(3S)-1-(PROP-2-ENOYL)PIPERIDIN-3-YL]PURIN-8-ONE

ON 0459 analog

ON 0459 ANALOG;ON-0459 ANALOG

ON-0459 analog

CS-1629

ONO-4059 (ONO-WG-307)

GS-4059

ONO-4059 (analog)

ONO-4059

(R)-9-(1-acryloylpiperidin-3-yl)-6-amino-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one

ONO-4059 analog(GS-4059 analog)

6-Amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one

ONO-4059 analogue

8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-

(S)-9-(1-acryloylpiperidin-3-yl)-6-amino-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one

GS-4059 analog

1351635-67-0

351635-67-0

C25H24N6O3