TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID
- Product Name
- TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID
- CAS No.
- 2484-60-8
- Chemical Name
- TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID
- Synonyms
- trans-2-Carbomethoxycyclohexane-1-carboxyic acid;TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID;cis-2-methoxycarbonylcyclohexane-1-carboxylic acid;trans-2-(Methoxycarbonyl)cyclohexanecarboxylic Acid;(1R,2R)-2-(Methoxycarbonyl)cyclohexane-1-carboxylicacid;(R,R)-Cyclohexane-1,2-dicarboxylic acid mono-methyl ester;rel-(1R,2R)-2-(Methoxycarbonyl)cyclohexane-1-carboxylic acid;1,2-Cyclohexanedicarboxylic acid, monomethyl ester, (1R,2R)-rel-;1,2-Cyclohexanedicarboxylic acid, monomethyl ester, (1R,2R)-rel- (9CI)
- CBNumber
- CB9280151
- Molecular Formula
- C9H14O4
- Formula Weight
- 186.21
- MOL File
- 2484-60-8.mol
TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID Property
- Boiling point:
- 72-75 °C(Press: 0.5-0.75 Torr)
- Density
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.43±0.28(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8342AD
- Product name
- trans-2-Carbomethoxycyclohexane-1-carboxyicacid
- Packaging
- 250mg
- Price
- $153
- Updated
- 2021/12/16
- Product number
- 18504
- Product name
- Trans-2-Carbomethoxycyclohexane-1-carboxyicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $251
- Updated
- 2021/12/16
- Product number
- 086448
- Product name
- trans-2-Carbomethoxycyclohexane-1-carboxyic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $252
- Updated
- 2021/12/16
- Product number
- 2223-1-47
- Product name
- (1R,2R)-2-(Methoxycarbonyl)cyclohexane-1-carboxylic acid
- Packaging
- 500mg
- Price
- $296
- Updated
- 2021/12/16
- Product number
- 2223-1-47
- Product name
- (1R,2R)-2-(Methoxycarbonyl)cyclohexane-1-carboxylic acid
- Packaging
- 1g
- Price
- $472
- Updated
- 2021/12/16
TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
67-56-1
13149-00-3
2484-60-8
General procedure for the synthesis of trans-2-(methoxycarbonyl)cyclohexanecarboxylic acid from methanol and cis-1,2-cyclohexanedicarboxylic anhydride: cis-1,2-cyclohexanedicarboxylic anhydride (7.0 g, 45.5 mmol) was dissolved in methanol (2 mL, 49.5 mmol), and the reaction was stirred for 1 hour at 100 °C. Upon completion of the reaction, the solvent was removed by evaporation to afford a white solid product, trans-2-(methoxycarbonyl)cyclohexanecarboxylic acid (8.46 g, 45.5 mmol, 100% yield), which could be used in subsequent steps without further purification. The melting point of the product was 67-69 °C. Infrared spectra (KBr) showed characteristic absorption peaks: ν 3060, 1710, 1670 cm-1. 1H NMR (400 MHz, CDCl3) data: δ 7.54 (s, 1H), 3.68 (s, 3H), 2.89-2.81 (m, 2H), 2.09-1.96 (m, 2H), 1.83-1.72 (m, 2H), 1.61-1.36 (m, 2H), 1.83-1.72 (m, 2H). 1.61-1.36 (m, 4H).13C NMR (100 MHz, CDCl3) data: δ 179.76, 174.06, 51.71, 42.48, 42.33, 26.25, 25.95, 23.74, 23.62.High-resolution mass spectrometry (ESI) analysis: [M-H]-calculated value for C9H13O4 of 185.0792 and the measured value was 185.0790.
References
[1] Letters in Organic Chemistry, 2018, vol. 15, # 5, p. 404 - 411
[2] Journal of Organic Chemistry, 2008, vol. 73, # 6, p. 2454 - 2457
[3] Organic and Biomolecular Chemistry, 2011, vol. 9, # 22, p. 7929 - 7940
[4] Patent: US2014/288314, 2014, A1. Location in patent: Paragraph 197; 198
[5] Chirality, 2015, vol. 27, # 10, p. 693 - 699
TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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