Phenoxyacetonitrile Property

Boiling point:

235-238 °C(lit.)

Density 

1.09 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.524(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

form 

clear liquid

color 

Colorless to Almost colorless

BRN 

2206192

CAS DataBase Reference

3598-14-9(CAS DataBase Reference)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36

RIDADR 

3276

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Phenoxyacetonitrile Chemical Properties,Usage,Production

Chemical Properties

clear light yellow-brown liquid

Uses

Phenoxyacetonitrile is a building block that has been used as a reactant for the preparation of [[(oxo)pyridazinyl]phenoxy]acetonitrile derivatives to be used as vasodilators.

Uses

Phenoxyacetonitrile may be used in the synthesis of:

• 2,4-dihydroxyphenoxyacetophenones
• methylthio(phenoxy)acetonitrile
• 2,4-diamino-5-(3,4,5-trimethoxyphenoxy)pyrimidine

References

[1] M. HAMANA T. H Y Fujimura. Reactions of quinoline and 4-chloroquinoline 1-oxides with phenoxyacetonitrile, chloromethylphenylsulfone, and methyl-thiomethyl-p-tolylsulfone[J]. Heterocycles, 1987, 25 1: 229-233. DOI:10.3987/S-1987-01-0229.
[2] A. Jonczyk* Essa H M. A SIMPLE PROCEDURE FOR THE PREPARATION OF (METHYL- AND PHENYLTHIO)ARYLOXYACETONITRILES[J]. Organic Preparations and Procedures International, 1993, 25 1: 690-693. DOI:10.1080/00304949309356267.
[3] STOGRYN E L. Synthesis of trimethoprim variations. Replacement of methylene by polar groupings[J]. Journal of Medicinal Chemistry, 1972, 15 2: 200-201. DOI:10.1021/jm00272a019.