Bulleyaconitine A

ChemicalBook > CAS DataBase List > Bulleyaconitine A

Product Name: Bulleyaconitine A
CAS No.: 107668-79-1
Chemical Name: Bulleyaconitine A
Synonyms: Bulleyaconitine;BULLEYACONITINE A;Bulleyaconi cine A;BULLEYACONITINE A(P);Bulleyaconitine A-RM;BULLEYACONITINE A(RG);Aconitane,Methanone deriv;Bulleyaconitine A USP/EP/BP;crassicauline A(bulleyaconitine;(-)-Syringaresinol 4-O-β-D-glucopyranosi
CBNumber: CB9291737
Molecular Formula: C35H49NO9
Formula Weight: 627.76
MOL File: 107668-79-1.mol

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Bulleyaconitine A Property

Boiling point:: 690.9±55.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at 2-8°C
solubility: DMSO: 125 mg/mL (199.12 mM)
form: Solid
pka: 13.12±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B689710
Product name: BulleyaconitineA
Packaging: 10mg
Price: $140
Updated: 2021/12/16

Usbiological

Product number: 300033
Product name: Bulleyaconitine A
Packaging: 20mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-3592
Product name: BulleyaconitineA
Purity: 99.09%
Packaging: 100mg
Price: $390
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb593800
Product name: Bulleyaconitine A
Packaging: 100mg
Price: $408
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb104628
Product name: Bulleyaconitine A
Purity: >98%,Standard References Grade
Packaging: 20mg
Price: $569.5
Updated: 2021/12/16

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Bulleyaconitine A Chemical Properties,Usage,Production

Description

Bulleyaconitine A is an aconitine-type two terpene alkaloid, and its molecular formula is C35H49NO10.?As early as 1980, bulleyaconitine was separated and extracted from a traditional analgesic and anti-inflammatory herb in the west of Yunnan called dianxi dula (or dianxi wutou) (Aconitum bulleyanum Diels), by the Kunming Institute of Botany, Chinese Academy of Sciences . At present, bulleyaconitine A can be separated from Aconitum plants, for example, dianxi wutou (Aconitum bulleyanum Diels), cujing wutou (Aconitum crassicaule W.T.?Wang), changhui wutou (Aconitum georgei Comber), and zhiyuan wutou (Aconitum transsectum Diels).

Physical properties

Appearance: white powder. Solubility: soluble in methanol, ethanol, chloroform, and ether; insoluble in water; and easily dissolved in dilute hydrochloric acid or dilute sulfuric acid . Melting point: 160–165?°C

History

In 1983, it was confirmed that bulleyaconitine A shows obvious analgesic and antiinflammatory effects by preclinical pharmacological tests . Clinical trials were carried out in 29 hospitals in 9 provinces in 1984. Bulleyaconitine A passed technical appraisals in May 1985 and was first formally put into production by Yunnan Honghe Pingbian pharmaceutical company, where it obtained the trade name “Bulleyaconitine A.” Bulleyaconitine A has been listed into the Pharmacopoeia of the People’s Republic of China (2015). In recent years, bulleyaconitine A has shown a great market growth and competitive power, owing to its exact curative effect and rapid clinical promotion in chronic disease and rheumatic immune disease.

Uses

Bulleyaconitine A is an agent that expresses long-lasting local anaesthetic properties used in the treatment of chronic pain and arthritis. Commonly used in China as a traditional medicine.

Pharmacology

1. Anti-inflammatory and analgesic effect. Bulleyaconitine A plays a significant anti-inflammatory effect by inhibiting the release of prostaglandins. The analgesic effect may be related to the rivalry of 5-HT and the inhibition of inflammatory chemokines in the brain, because inhibition of PGE2 release may lead to disinhibition of β-endorphin . Further studies showed that bulleyaconitine A achieved the analgesic effect by effectively reducing sodium ion current, the electrophysiological basis on which pain conduction is dependent . Zhanguo Niu et?al. found that bulleyaconitine A could be used to treat mild and moderate burn pain, with less adverse reactions and no addiction . Thus, bulleyaconitine A may be suitable for long-term use as a choice of analgesic therapy for burn pain. Recently, through clinical observation on the effect of bulleyaconitine A treatment in acute gouty arthritis, some scholars discovered that bulleyaconitine A brought about good effect and could effectively improve the clinical symptoms of patients by taking 0.4?mg bulleyaconitine A orally three times in daily .
2. Immune regulation. Bulleyaconitine A has obvious inhibitory effects to immune cells involved in joint inflammation, which may have a close relationship to its clinical anti-inflammatory effect. Ye Lu et?al. studied the influence of bulleyaconitine A on partial immune functions of BALB/c mice and found that 0.32?mg/kg bulleyaconitine A inhibits some immune functions of BALB/c mice . Moreover, it was reported that bulleyaconitine A significantly inhibited the phagocytic function and the ability to secrete nitric oxide (NO) of macrophages .
3. Other pharmacological effects. An injection of 0.1 mg/kg bulleyaconitin A in fasting rat can inhibit the formation of corneal neovascularization induced by alkali burn . Bulleyaconitine A also has local anesthesia and antipyretic effect. Besides, bulleyaconitine A can be used for the treatment of lumbar muscle strain, scapulohumeral periarthritis, and sprain of limbs.

Clinical Use

1. Rheumatic immune disease. Since listing, bulleyaconitine A has been applied in clinical treatment for rheumatoid arthritis and osteoarthritis, receiving good curative effects.
2. Chronic pain. Bulleyaconitine A does not belong to NSAID, and it exerts its effects by regulating the sodium ion channel. So there is little psychological dependence and organ toxicity, avoiding gastrointestinal/cardiovascular/renal adverse reactions and drug dependence or other potential dangers caused by NSAID and opioid analgesics.

Bulleyaconitine A Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bulleyaconitine A manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.

Product: Bulleya conitine A 107668-79-1
Price: US $120.00/KG
Min. Order: 1250KG
Purity: 99%
Supply Ability: 330T
Release date: 2023-06-08

Shanghai Standard Technology Co., Ltd.

Product: Bulleyaconitine A 107668-79-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: Bulleyaconitine A 107668-79-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

107668-79-1, Bulleyaconitine ARelated Search:

4'-Hydroxynonanophenone N-OCTADECANOPHENONE Bulleyaconitine A p-hexadecylphenol 1-PHENYLOCTADECANE 4-tetradecylphenol 4-n-Octadecylphenol CYCLOHEXYL 4-METHOXYPHENYL KETONE TETRAHYDROIONYL ACETATE ISO-METHYL TETRAHYDROIONYL ACETATE N-HEXADECANOPHENONE N-TETRADECANOPHENONE CYCLOPENTYL 4-METHOXYPHENYL KETONE CIS-(2-AMINO-CYCLOPENTYL)-METHANOL N-HEPTADECANOPHENONE N-TRIDECANOPHENONE 3-HYDROXY-2-METHYL-1-PHENYL-HEXAN-1-ONE 1-(4-HYDROXYPHENYL)DODECAN-1-ONE

16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-y-6

methanone,((1-alpha,6-alpha,14-alpha,16-beta)-8-(acetyloxy)-20-ethyl-13-hydrox

BULLEYACONITINE A

METHANONE, [(1,6,14,16)-8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)-

BULLEYACONITINE A: METHANONE, [(1,6,14,16) -8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)-,

BULLEYACONITINE A(P)

20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-

Methanone, [(1α,6α,14α,16β) -8-(acetyloxy)-

Bulleyaconi cine A

BULLEYACONITINE A(RG)

Aconitane,Methanone deriv

Methanone, [(1a,6a,14a,16b)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-

Bulleyaconitine

((1-α,6-α,14-α,16-β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-methanone

Bulleyaconitine A, 98%, from Aconitum kusnezoffii Rchb.

crassicauline A(bulleyaconitine

Methanone, [(1α,6α,14α,16β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl) aconitan-14-yl](4-methoxyphenyl)-

Bulleyaconitine A USP/EP/BP

(-)-Syringaresinol 4-O-β-D-glucopyranosi

Bulleyaconitine A-RM

107668-79-1

79572-91-9

C35H49NO9

standardized herbal extract

Inhibitors

Natural Plant Extract

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).