4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

Product Name: 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile
CAS No.: 1263373-43-8
Chemical Name: 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile
Synonyms: NVP-2;inhibit,Apoptosis,Cyclin dependent kinase,CDK,NVP-2,Inhibitor,CRBN,CDK9,Leukemia,NVP 2,NVP2;4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylami)cyclohexylami)-2,4'-bipyridin-6-ylami)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-[[[5’-Chloro-2’-[[trans-4-[[(R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]-[2,4’-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile;4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile;2H-Pyran-4-carbonitrile, 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-
CBNumber: CB92995844
Molecular Formula: C27H37ClN6O2
Formula Weight: 513.07
MOL File: 1263373-43-8.mol

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4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Property

Boiling point:: 704.5±60.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Ethanol: soluble
form: A solid
pka: 9.14±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3069
Product name: NVP-2
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $207
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML3069
Product name: NVP-2
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $827
Updated: 2022/05/15

Tocris

Product number: 6535
Product name: NVP2
Purity: ≥97%(HPLC)
Packaging: 5
Price: $238
Updated: 2021/12/16

TRC

Product number: N925775
Product name: NVP-2
Packaging: 1mg
Price: $495
Updated: 2021/12/16

Usbiological

Product number: 461045
Product name: NVP-2
Packaging: 1mg
Price: $885
Updated: 2021/12/16

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4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Chemical Properties,Usage,Production

Uses

NVP-2, is a CDK9 inhibitor with an IC50 of 0.5 nM.

storage

Store at -20°C

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Suppliers

China 58 United Kingdom 1 United States 5 Global 64

Shanghai Tachizaki Biomedical Research Center

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1263373-43-8, 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrileRelated Search:

4'-Benzyloxy-2'-hydroxyacetophenone

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

NVP-2

4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile

2H-Pyran-4-carbonitrile, 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-

inhibit,Apoptosis,Cyclin dependent kinase,CDK,NVP-2,Inhibitor,CRBN,CDK9,Leukemia,NVP 2,NVP2

4-[[[5’-Chloro-2’-[[trans-4-[[(R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]-[2,4’-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylami)cyclohexylami)-2,4'-bipyridin-6-ylami)methyl)tetrahydro-2H-pyran-4-carbonitrile

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

1263373-43-8