4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

Product Name: 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile
CAS No.: 1263373-43-8
Chemical Name: 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile
Synonyms: NVP-2;inhibit,Apoptosis,Cyclin dependent kinase,CDK,NVP-2,Inhibitor,CRBN,CDK9,Leukemia,NVP 2,NVP2;4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylami)cyclohexylami)-2,4'-bipyridin-6-ylami)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-[[[5’-Chloro-2’-[[trans-4-[[(R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]-[2,4’-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile;4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile;2H-Pyran-4-carbonitrile, 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-
CBNumber: CB92995844
Molecular Formula: C27H37ClN6O2
Formula Weight: 513.07
MOL File: 1263373-43-8.mol

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4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Property

Boiling point:: 704.5±60.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Ethanol: soluble
form: A solid
pka: 9.14±0.40(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3069
Product name: NVP-2
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $207
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML3069
Product name: NVP-2
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $827
Updated: 2022/05/15

Tocris

Product number: 6535
Product name: NVP2
Purity: ≥97%(HPLC)
Packaging: 5
Price: $238
Updated: 2021/12/16

TRC

Product number: N925775
Product name: NVP-2
Packaging: 1mg
Price: $495
Updated: 2021/12/16

Usbiological

Product number: 461045
Product name: NVP-2
Packaging: 1mg
Price: $885
Updated: 2021/12/16

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4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Chemical Properties,Usage,Production

Uses

NVP-2, is a CDK9 inhibitor with an IC50 of 0.5 nM.

storage

Store at -20°C

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Suppliers

China 63 United Kingdom 1 United States 5 Global 69

Shanghai Tachizaki Biomedical Research Center

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View Lastest Price from 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: NVP-2 1263373-43-8
Price: US $0.00-0.00/MG
Min. Order: 1MG
Purity: 98
Supply Ability: 10G
Release date: 2024-10-29

1263373-43-8, 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrileRelated Search:

4'-Benzyloxy-2'-hydroxyacetophenone

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

NVP-2

4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile

2H-Pyran-4-carbonitrile, 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-

inhibit,Apoptosis,Cyclin dependent kinase,CDK,NVP-2,Inhibitor,CRBN,CDK9,Leukemia,NVP 2,NVP2

4-[[[5’-Chloro-2’-[[trans-4-[[(R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]-[2,4’-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylami)cyclohexylami)-2,4'-bipyridin-6-ylami)methyl)tetrahydro-2H-pyran-4-carbonitrile

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

1263373-43-8