Gene, mRNA, and precursor Receptors Biological functions

XENIN 25

Gene, mRNA, and precursor Receptors Biological functions
Product Name
XENIN 25
Chemical Name
XENIN 25
Synonyms
XENIN;HEP-COP;XENIN 25;FLJ26320;XENIN 25 (HUMAN);alpha coat protein;MLTKFETKSARVKGLSFHPKRPWIL;Anti-COPA antibody produced in goat;coatomer protein complex, subunit alpha;MET-LEU-THR-LYS-PHE-GLU-THR-LYS-SER-ALA-ARG-VAL-LYS-GLY-LEU-SER-PHE-HIS-PRO-LYS-ARG-PRO-TRP-ILE-LEU
CBNumber
CB9301678
Molecular Formula
C139H224N38O32S
Formula Weight
2971.57
MOL File
Mol file
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XENIN 25 Property

storage temp. 
−20°C
solubility 
H2O: soluble
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB2501979
Product name
Anti-COPA antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100μG
Price
$545
Updated
2023/01/07
Usbiological
Product number
X1013
Product name
Xenin 25
Packaging
1mg
Price
$531
Updated
2021/12/16
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XENIN 25 Chemical Properties,Usage,Production

Gene, mRNA, and precursor

The human COPA gene is an approximately 54.7-kb long gene that maps to the 1p23.2. Human COPA mRNA codes for a 1233-aa long protein. ProXen, the 35-aa N-terminal region, is cleaved into a 25-aa mature Xen.

Receptors

The action of Xen is mediated by neurotensin receptor subtype 1 (NTSR1); however, several biological actions of Xen are independent of NTSR1. Xen activates ERK signaling in subpopulations of hypothalamic neurons.

Biological functions

Xen-25 exerts multiple physiological functions in peripheral and central tissues. Xen-25 stimulates exocrine pancreatic secretion and is involved in glucose homeostasis. In the GI tract, Xen-25 regulates gastric and intestinal motility. Xen-25 induces gall bladder contraction. In central tissues, the icv administration of Xen-25 suppresses food intake.

Description

A 25-aa peptide with six C-terminal aa in common with the amphibian octapeptide xenopsin was identified from the human gastric mucosa in 1992 and named xenin. Xen was identified in various mammals, including dogs, pigs, rats, guinea pigs, and rabbits, in 1995.

Clinical Use

A novel hybrid peptide, exendin-4/gastrin/Xen-8, was developed to improve the metabolic status in obese diabetic mice.21 In addition, Xen-8, a fragment of Xen-25, possesses the same biological functions as Xen-25. Thus, not only Xen-25, but also Xen-8 and the hybrid peptide are expected to exert beneficial metabolic effects in relation to new therapeutic approaches for diabetes and obesity.

Structure and conformation

Xen is highly conserved across species from insects to mammals. It is cleaved from the N-terminus of its precursor, coatomer protein α (COPA), by an aspartic protease, presumably cathepsin E. Xen has close structural similarities to neurotensin, and is a part of the neurotensin/xenopsin/xenin family along with neuromedin N and kinetensin/NRP. Xen consists of 25 aa, and the putative aa sequence of Xen based on the COPA gene database is evolutionarily conserved from yeast to mammals. The aa sequence of Xen is identical in the acorn worm, salmon, wild turkey, Chinese hamster, mouse, bull, rhesus macaque, and human. The bioactive C-terminal octapeptide of Xen, termed Xen-8, is a natural metabolite that circulates in the plasma.

XENIN 25 Preparation Products And Raw materials

Raw materials

Preparation Products

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XENIN 25 Suppliers

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6756
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Ontores Biotech
Tel
0571-88760729 18072970094
Email
supports@ontorespeptide.com
Country
China
ProdList
2696
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
6445
Advantage
58
Shanghai Toyang Biotechnology Co., LTD
Tel
021-59555769 13524932310
Fax
021-50342869
Email
1405894150@qq.com
Country
China
ProdList
8221
Advantage
58

XENIN 25Related Search:


  • H-MET-LEU-THR-LYS-PHE-GLU-THR-LYS-SER-ALA-ARG-VAL-LYS-GLY-LEU-SER-PHE-HIS-PRO-LYS-ARG-PRO-TRP-ILE-LEU-OH
  • MET-LEU-THR-LYS-PHE-GLU-THR-LYS-SER-ALA-ARG-VAL-LYS-GLY-LEU-SER-PHE-HIS-PRO-LYS-ARG-PRO-TRP-ILE-LEU
  • alpha coat protein
  • Anti-COPA antibody produced in goat
  • coatomer protein complex, subunit alpha
  • FLJ26320
  • HEP-COP
  • MLTKFETKSARVKGLSFHPKRPWIL
  • XENIN
  • XENIN 25
  • XENIN 25 (HUMAN)
  • H-Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg-Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu-O
  • C139H224N38O32S
  • C139H224N38O32S1
  • Hormones
  • Cytokines, Growth Factors and Hormones
  • Obesity Research
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Peptide