ICA 110381
- Product Name
- ICA 110381
- CAS No.
- 325457-99-6
- Chemical Name
- ICA 110381
- Synonyms
- ICA-11038;ICA 110381;ICA 110381; ICA110381;ICA 110381 (Compound 16);4-CHLOR-N-(6-CHLOR-PYRIDIN-3-YL)-BENZAMID;4-Chloro-N-(6-chloro-3-pyridinyl)benzamide;4-Chloro-N-(6-chloro-pyridin-3-yl)-benzamide;Benzamide, 4-chloro-N-(6-chloro-3-pyridinyl)-;inhibit,ICA 110381,Potassium Channel,ICA-110381,KcsA,ICA110381,Inhibitor
- CBNumber
- CB93037314
- Molecular Formula
- C12H8Cl2N2O
- Formula Weight
- 267.11
- MOL File
- 325457-99-6.mol
ICA 110381 Property
- Boiling point:
- 336.8±37.0 °C(Predicted)
- Density
- 1.440±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO (up to 26 mg/ml) or in Ethanol (up to 5 mg/ml).
- form
- solid
- pka
- 11.34±0.70(Predicted)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4950
- Product name
- ICA110381
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $154
- Updated
- 2021/12/16
- Product number
- 4950
- Product name
- ICA110381
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $628
- Updated
- 2021/12/16
- Product number
- I163600
- Product name
- ICA110381
- Packaging
- 100mg
- Price
- $1095
- Updated
- 2021/12/16
- Product number
- 255482
- Product name
- ICA 110381
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- 452171
- Product name
- ICA 110381
- Packaging
- 10mg
- Price
- $425
- Updated
- 2021/12/16
ICA 110381 Chemical Properties,Usage,Production
Description
ICA-110381 (325457-99-6) is a KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 μM (KCNQ1 IC50=15 μM).1?KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activity?in vivo.2
Uses
ICA 110381 was used to study the pharmacological activities as it selectively activated human KCNQ2 expressed in Chinese hamster ovary, damped neuronal excitability in rat hippocampal CA1 cell and showed anticonvulsant activity in amygdala-kindled rat.
storage
Store at +4°C
References
1) Amato?et al. (2011),?N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy; Sci. ACS Med. Chem. Lett.,?2?481 2) Boehlen?et al. (2013),?The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)benzamid displays anticonvulsant potential; Br. J. Pharmacol.,?168?1182