methyl 3-nitro-4-bromomethylbenzoate

Product Name: methyl 3-nitro-4-bromomethylbenzoate
CAS No.: 88089-94-5
Chemical Name: methyl 3-nitro-4-bromomethylbenzoate
Synonyms: methyl 3-nitro-4-bromomethylbenzoate;Methyl 4-(bromomethyl)-3-nitrobenzoate;4-(bromomethyl)-3-nitrobenzoic acid methyl ester;Benzoic acid, 4-(bromomethyl)-3-nitro-, methyl ester
CBNumber: CB93037783
Molecular Formula: C9H8BrNO4
Formula Weight: 274.07
MOL File: 88089-94-5.mol

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methyl 3-nitro-4-bromomethylbenzoate Property

Boiling point:: 364.5±32.0 °C(Predicted)
Density: 1.624±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 301380
Product name: Methyl 4-(bromomethyl)-3-nitrobenzoate
Packaging: 250.00mg
Price: $60
Updated: 2026/05/19

Matrix Scientific

Product number: 301380
Product name: Methyl 4-(bromomethyl)-3-nitrobenzoate
Packaging: 1.00g
Price: $147
Updated: 2026/05/19

Matrix Scientific

Product number: 301380
Product name: Methyl 4-(bromomethyl)-3-nitrobenzoate
Packaging: 5.00g
Price: $467
Updated: 2026/05/19

Synthonix

Product number: M51489
Product name: Methyl 4-(bromomethyl)-3-nitrobenzoate
Purity: 95+%
Packaging: 250mg
Price: $170
Updated: 2026/05/06

Synthonix

Product number: M51489
Product name: Methyl 4-(bromomethyl)-3-nitrobenzoate
Purity: 95+%
Packaging: 1g
Price: $360
Updated: 2026/05/06

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methyl 3-nitro-4-bromomethylbenzoate Chemical Properties,Usage,Production

Uses

methyl 4-(bromomethyl)-3-nitrobenzoate is a useful reactant used for the preparation of nitrobenzyl-substituted α-hydroxy esters, (hydroxy)oxindoles, and benzosultams.

Synthesis

7356-11-8

88089-94-5

General procedure for the synthesis of methyl 4-(bromomethyl)-3-nitrobenzoate from methyl 4-methyl-3-nitrobenzoate: in a 1000 mL round-bottomed flask, a nitrogen purge was performed first and an inert nitrogen atmosphere was maintained. Methyl 4-methyl-3-nitrobenzoate (10 g, 51.24 mmol, 1.00 eq.), N-bromosuccinimide (NBS, 9.13 g, 51.29 mmol, 1.00 eq.), benzoyl peroxide (BPO, 1.24 g, 5.12 mmol, 0.10 eq.), and carbon tetrachloride (400 mL) were added sequentially. The reaction mixture was stirred at 100 °C for 15 hours. After completion of the reaction, the crude product was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (gradient elution in the ratio of 0:1 to 1:9). Finally, 11.1 g of methyl 4-(bromomethyl)-3-nitrobenzoate was obtained in 79% yield, and the product was a yellow oil. The crude product obtained can be directly used in the next reaction without further purification.

References

[1] Patent: US2015/315198, 2015, A1. Location in patent: Paragraph 1365; 1366
[2] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 93
[3] Tetrahedron Letters, 2002, vol. 43, # 34, p. 5949 - 5952
[4] Patent: WO2013/131408, 2013, A1. Location in patent: Page/Page column 73
[5] Patent: US6348474, 2002, B1. Location in patent: Page column 87

methyl 3-nitro-4-bromomethylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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methyl 3-nitro-4-bromomethylbenzoate Suppliers

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88089-94-5, methyl 3-nitro-4-bromomethylbenzoateRelated Search:

methyl 3-nitro-4-bromomethylbenzoate

Methyl 4-(bromomethyl)-3-nitrobenzoate

4-(bromomethyl)-3-nitrobenzoic acid methyl ester

Benzoic acid, 4-(bromomethyl)-3-nitro-, methyl ester

88089-94-5