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Lefamulin

Product Name
Lefamulin
CAS No.
1061337-51-6
Chemical Name
Lefamulin
Synonyms
2-[[(1R,2R,4R)-4-Amino-2-hydroxycyclohexyl]thio]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester;BC 3781;Lefamulin;Lefamulin(BC-3781);Lefamulin, 10 mM in DMSO;(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate;Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
CBNumber
CB93039318
Molecular Formula
C28H45NO5S
Formula Weight
507.73
MOL File
1061337-51-6.mol
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Lefamulin Property

Boiling point:
618.6±55.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 16 mg/mL; DMSO: 12 mg/mL; Ethanol: 3 mg/mL; PBS (pH 7.2): 0.25 mg/mL
form 
A solid
pka
14.45±0.60(Predicted)
color 
White to off-white
InChIKey
KPVIXBKIJXZQJX-FCEONZPQSA-N
SMILES
C(O[C@@H]1C[C@](C=C)(C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@]2([H])C(=O)CC3)(=O)CS[C@@H]1CC[C@@H](N)C[C@H]1O
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
Hazard Classifications
STOT SE 2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SBR00096
Product name
Lefamulin
Purity
≥98% (HPLC), powder
Packaging
1 unit
Price
$68.55
Updated
2025/07/31
DC Chemicals
Product number
007448
Product name
Lefamulin(BC-3781)
Packaging
004
Price
$450
Updated
2021/12/16
DC Chemicals
Product number
DC8172
Product name
Lefamulin(BC-3781)
Purity
>98%
Packaging
100mg
Price
$1000
Updated
2021/12/16
DC Chemicals
Product number
DC8172
Product name
Lefamulin(BC-3781)
Purity
>98%
Packaging
250mg
Price
$1700
Updated
2021/12/16
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Lefamulin Chemical Properties,Usage,Production

Uses

Lefamulin is an antibiotic medication used in the treatment of adults with community-acquired bacterial pneumonia.

Biological Activity

Lefamulin inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome. Specifically, it binds to the peptidyl transferase center of the ribosome and inhibits the transfer of amino acids to growing polypeptide chains, which leads to the inhibition of bacterial protein synthesis and bacterial death. Lefamulin is active against a wide range of Gram-positive bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA), as well as some atypical bacteria such as Legionella species. It has also been shown to have activity against some Gram-negative bacteria, including Haemophilus influenzae and Moraxella catarrhalis.

Synthesis

synthesis route of Lefamulin

in vivo

Lefamulin (10-140 mg/kg, s.c.) shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model[4].
Lefamulin (1.25-160 mg/kg, s.c.) shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice[5].

Animal Model:LPS-induced lung neutrophilia mouse model[4]
Dosage:10-140 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Reduced BALF neutrophil cell counts.
Reduced pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, and GM-CSF), chemokine (CXCL-1, CXCL-2, and CCL-2) and MMP-9 levels in mouse lung tissue.

Lefamulin Preparation Products And Raw materials

Raw materials

Preparation Products

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Lefamulin Suppliers

China 73 India 1 United States 3 Global 77
CHAUNGZERUI
Tel
15301951213
Email
aolinaijiao@sina.com
Country
China
ProdList
34
Advantage
58
BEIJING INNO-TECH PHARMIC TECHNOLOGY CO.,LTD
Tel
15011485209
Country
China
ProdList
145
Advantage
58
ZhengZhou Yimi Pharma R&D Co.,LTD.
Tel
15393710992
Email
375000787@QQ.com
Country
China
ProdList
21
Advantage
58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Email
wtx@bayeebio.com
Country
China
ProdList
229
Advantage
61
Yingchun Branch of Heilongjiang Wusuli River Pharmaceutical Co., LTD
Tel
15545570712
Email
474485363@qq.com
Country
China
ProdList
154
Advantage
58
Shaanxi Zhong Zhi Biao Pin Pharmaceutical technology Co., LTD
Tel
029-89239927 18009291534
Email
18009291534@163.com
Country
China
ProdList
401
Advantage
58
Quality Control Solutions Ltd.
Tel
66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18364
Advantage
56
Chengdu Miracle Pharmaceutical Co., Ltd.
Tel
028-86136736 19130631884
Fax
028-85265615
Email
sales@mic-pharma.com
Country
China
ProdList
339
Advantage
56
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Email
enkepharma@126.com;sale@enkepharma.com
Country
China
ProdList
2305
Advantage
55
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View Lastest Price from Lefamulin manufacturers

Zhengzhou Anbu Chem Co.,Ltd
Product
Lefamulin 1061337-51-6
Price
US $0.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
1000KGS
Release date
2023-06-13

1061337-51-6, LefamulinRelated Search:


  • Lefamulin
  • 2-[[(1R,2R,4R)-4-Amino-2-hydroxycyclohexyl]thio]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
  • BC 3781
  • Lefamulin(BC-3781)
  • Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
  • (3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate
  • Lefamulin, 10 mM in DMSO
  • 1061337-51-6
  • C28H45NO5S
  • API