RO5263397

Product Name: RO5263397
CAS No.: 1357266-05-7
Chemical Name: RO5263397
Synonyms: RO5263397;RO5263397,RO-5263397;RO5263397, 10 mM in DMSO;Chenodeoxycholic Acid Impurity 21;(S)-4-(3-FLUORO-2-METHYLPHENYL)-4,5-DIHYDROOXAZOL-2-AMINE;(S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydrooxazole-2-amine;2-Oxazolamine, 4-(3-fluoro-2-methylphenyl)-4,5-dihydro-, (4S)-
CBNumber: CB93039893
Molecular Formula: C10H11FN2O
Formula Weight: 194.21
MOL File: 1357266-05-7.mol

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RO5263397 Property

Boiling point:: 303.9±52.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 260 mg/mL (1338.76 mM; Need ultrasonic)
form: powder
pka: 7.68±0.70(Predicted)
color: white to beige
optical activity: [α]/D +77 to +88°, c = 1.0 in methanol
InChI: 1S/C10H11FN2O/c1-6-7(3-2-4-8(6)11)9-5-14-10(12)13-9/h2-4,9H,5H2,1H3,(H2,12,13)/t9-/m1/s1
InChIKey: IOHOUWIYOVWGHV-SECBINFHSA-N
SMILES: NC1=N[C@@H](C2=CC=CC(F)=C2C)CO1

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2225
Product name: RO5263397
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $113
Updated: 2026/04/30

Sigma-Aldrich

Product number: SML2225
Product name: RO5263397
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $454
Updated: 2026/04/30

Biorbyt Ltd

Product number: orb1708657
Product name: RO5263397
Purity: 99.37%
Packaging: 1mg
Price: $80
Updated: 2026/05/06

Biorbyt Ltd

Product number: orb1708657
Product name: RO5263397
Purity: 99.37%
Packaging: 5mg
Price: $120
Updated: 2026/05/06

Biorbyt Ltd

Product number: orb1708657
Product name: RO5263397
Purity: 99.37%
Packaging: 1mlx10mM(inDMSO)
Price: $120
Updated: 2026/05/06

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RO5263397 Chemical Properties,Usage,Production

Uses

RO 5263397 is a trace amine-associated receptor 1 agonist (TAAR1).

Biological Activity

RO5256390 is an orally available partial agonist th at targets trace amine-associated receptor 1 (TAAR1) with high affinity (Ki in nM = 0.9/mouse, 4.1/human, 9.1/rat, 24/monkey TARR1), potency (EC50 in nM/relative efficacy with respect to β-phenylethylamine = 1.3/0.59/mouse, 17/0.81/human, 47/0.76/rat, 251/0.85/monkey TARR1-dependent cellular cAMP production), and selectivity (by a 112-receptor/channel/transporter and a 42-enzyme panel), without agonistic activity toward mouse TAAR4-expressing cells even at a high concentration of 30 μM. When applied via oral administration (0.003-1 mg/kg), RO5256390 exhibits similar in vivo efficacy as the full agonist RO5256390 in blocking psychostimulants-induced hyperlocomotion in mice.

in vivo

RO5263397 (0.1-1.0mg/kg; p.o.; dosing at the mid-light phase (ZT6)) increases wake time at 0.3 and 1mg/kg^[2].
RO5263397 (0.3 and 1.0mg/kg; p.o.) decreases NREM time in WT mice. RO5263397 (0.3 and 1.0mg/kg; p.o.; in OE mice) powerfully increases W time in OE mice for 5-6h. NREM sleep is suppressed for 4-6h and REM sleep is almost completely suppressed for 6h after all doses of RO5263397^[3].

Animal Model:	Adult 4-5-month-old male WT littermates (C57BL/6 background)^[2]
Dosage:	0.1, 0.3, 1mg/kg
Administration:	p.o.; dosing at the mid-light phase (ZT6)
Result:	Increased wake time at 0.3 and 1mg/kg

RO5263397 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO5263397 Suppliers

China 23 United States 6 Global 29

Twochem Co.Ltd

Tel: 021-021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
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Shanghai Chaolan Chemical Technology Center

Tel: QQ：65489617 19372819560
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
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Jiangsu aikang biomedical research and development co., LTD

Tel: 025-58859352 17714375163
Email: qzhang@aikonchem.com
Country: China
ProdList: 15525
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Shanghai Minhan Pharmaceutical Technology Co., Ltd.

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Email: 2816925681@qq.com
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Shanghai Dexuan Pharmaceutical Technology Co., Ltd

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Email: dexuanyiyao@126.com
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Nantong Hi-Future Biotechnology Co., Ltd

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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
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Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
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1357266-05-7, RO5263397Related Search:

RO5263397

(S)-4-(3-FLUORO-2-METHYLPHENYL)-4,5-DIHYDROOXAZOL-2-AMINE

RO5263397,RO-5263397

2-Oxazolamine, 4-(3-fluoro-2-methylphenyl)-4,5-dihydro-, (4S)-

Chenodeoxycholic Acid Impurity 21

RO5263397, 10 mM in DMSO

(S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydrooxazole-2-amine

1357266-05-7

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