7-bromo-3-methylquinoline
- Product Name
- 7-bromo-3-methylquinoline
- CAS No.
- 1375108-41-0
- Chemical Name
- 7-bromo-3-methylquinoline
- Synonyms
- 7-bromo-3-methylquinoline;Quinoline, 7-bromo-3-methyl-
- CBNumber
- CB93050023
- Molecular Formula
- C10H8BrN
- Formula Weight
- 222.08
- MOL File
- 1375108-41-0.mol
7-bromo-3-methylquinoline Property
- Boiling point:
- 313.8±22.0 °C(Predicted)
- Density
- 1.488±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.59±0.25(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 182799
- Product name
- 7-Bromo-3-methylquinoline
- Purity
- 95%
- Packaging
- 5g
- Price
- $1733
- Updated
- 2021/12/16
- Product number
- A210771
- Product name
- 7-Bromo-3-methylquinoline
- Purity
- 95%
- Packaging
- 100mg
- Price
- $221
- Updated
- 2021/12/16
- Product number
- A210771
- Product name
- 7-Bromo-3-methylquinoline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $353
- Updated
- 2021/12/16
- Product number
- 1375108410
- Product name
- 7-Bromo-3-methylquinoline
- Packaging
- 250mg
- Price
- $438.78
- Updated
- 2021/12/16
- Product number
- A210771
- Product name
- 7-Bromo-3-methylquinoline
- Purity
- 95%
- Packaging
- 1g
- Price
- $882
- Updated
- 2021/12/16
7-bromo-3-methylquinoline Chemical Properties,Usage,Production
Synthesis
59278-65-8
123-38-6
1375108-41-0
General procedure for the synthesis of 7-bromo-3-methylquinoline from 2-amino-4-bromobenzaldehyde and propionaldehyde: KOH (5.61 g, 100 mmol) was dissolved in ethanol (50 mL) to prepare a solution, which was subsequently added drop-wise to a reaction flask containing a 2-amino-4-bromobenzaldehyde (60.6 g, 303 mmol) and propionaldehyde (17.6 g, 303 mmol ) in a reaction flask of the mixture. Anhydrous ethanol (200 mL) was added to the reaction system under nitrogen protection. The reaction mixture was heated to reflux and the reflux reaction was maintained for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated by rotary evaporator to remove ethanol. Water was added to the concentrated mixture and extracted with dichloromethane (3 x 100 mL). All organic layers were combined, washed with water and dried over anhydrous sodium sulfate, after which it was concentrated under vacuum. The crude product obtained was ground with ether to give the final 7-bromo-3-methylquinoline (48.6 g, 219 mmol, 72% yield) as a light brown solid. Mass spectrum (electrospray ionization) m/e 221.9, 223.9 [M + H]+ (bromine isotope mode).
References
[1] Patent: WO2014/108858, 2014, A1. Location in patent: Page/Page column 36
[2] Patent: WO2016/30443, 2016, A1. Location in patent: Page/Page column 99-100
7-bromo-3-methylquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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