Vps34-IN-1
- Product Name
- Vps34-IN-1
- CAS No.
- 1383716-33-3
- Chemical Name
- Vps34-IN-1
- Synonyms
- CS-2377;Vps34-IN-1;inhibit,Autophagy,Vps34IN1,PI3K,Vps-34-IN-1,Inhibitor,Phosphoinositide 3-kinase,Vps34 IN 1;1-[[2-[(2-Chloro-4-pyridinyl)amino]-4'-(cyclopropylmethyl)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-2-propanol;1-((2-((2-chloropyridin-4-yl)amino)-4'-(cyclopropylmethyl)-[4,5'-bipyrimidin]-2'-yl)amino)-2-methylpropan-2-ol;1-((2-((2-Chloropyridin-4-yl)amino)-4'-(cyclopropylmethyl)-[4,5'-bipyrimidin]-2'-yl)amino)-2-methylpropan-2-ol;2-Propanol, 1-[[2-[(2-chloro-4-pyridinyl)amino]-4'-(cyclopropylmethyl)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-
- CBNumber
- CB93053943
- Molecular Formula
- C21H24ClN7O
- Formula Weight
- 425.91
- MOL File
- 1383716-33-3.mol
Vps34-IN-1 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17392
- Product name
- VPS34-IN1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $27
- Updated
- 2024/03/01
- Product number
- 17392
- Product name
- VPS34-IN1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $88
- Updated
- 2024/03/01
- Product number
- 17392
- Product name
- VPS34-IN1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $149
- Updated
- 2024/03/01
- Product number
- 17392
- Product name
- VPS34-IN1
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $236
- Updated
- 2024/03/01
- Product number
- V785030
- Product name
- Vps34-IN-1
- Packaging
- 1mg
- Price
- $65
- Updated
- 2021/12/16
Vps34-IN-1 Chemical Properties,Usage,Production
Uses
Vps34-IN-1 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (VPS34) (1). VPS34 inhibitors can be used to investigate autophagic processes (2).
Biological Activity
vps34-in1 is a vps34 inhibitor.the vacuolar protein sorting 34 (vps34) class iii phosphoinositide 3-kinase (pi3k) phosphorylates phosphatidylinositol (ptdins) to generate ptdins(3)p that regulates membrane trafficking processes through its ability to recruit a subset of proteins possessing ptdins(3)p-binding phox homology (px) and fyve domains.
in vitro
vps34-in1 was identified to be able to inhibit in-vitro vps34, but did not significantly inhibit the activity of tested 340 protein kinases or 25 lipid kinases that include all isoforms of class i and class ii pi3ks. treatment of vps34-in1 to cells dose-dependently induced a quick dispersal of a specific ptdins(3)p-binding probe, without altering the ability of class i pi3k to regulate akt. moreover, vps34-in1 could also induce a quick ~50-60% loss of sgk3 phosphorylation within 1 min. however, vps34-in1 could not inhibit activity of the sgk2 isoform without a ptdins(3)p-binding px domain. in addition, the combination of vps34-in1 and class i pi3k inhibitor of gdc-0941 resulted in the reduced sgk3 activity ~80-90%. therefore, these data demonstrated that vps34-in1 would be a useful probe to delineate physiological roles of the vps34 and the combination of class i such as gdc-0941 and class iii such as vps34-in1 pi3k inhibitors could be used to better analyse the roles and regulation of the elusive class ii pi3k [1].
IC 50
25 nm
References
[1] bago r et al. characterization of vps34-in1, a selective inhibitor of vps34, reveals that the phosphatidylinositol 3-phosphate-binding sgk3 protein kinase is a downstream target of class iii phosphoinositide 3-kinase. biochem j.2014 nov 1;463(3):413-27.
Vps34-IN-1 Preparation Products And Raw materials
Raw materials
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