ChemicalBook > CAS DataBase List > 2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid

2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid

Product Name
2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid
CAS No.
1255945-85-7
Chemical Name
2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid
Synonyms
DYFNQNVMHCQXDI-UHFFFAOYSA-N;Benzeneacetic acid, 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid
CBNumber
CB93063779
Molecular Formula
C14H18BFO4
Formula Weight
280.1
MOL File
1255945-85-7.mol
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2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid Property

Boiling point:
410.9±40.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
4.29±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B434783
Product name
[4-fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]aceticacid
Packaging
100mg
Price
$105
Updated
2021/12/16
AK Scientific
Product number
9699AF
Product name
[4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]aceticacid
Packaging
100mg
Price
$127
Updated
2021/12/16
AK Scientific
Product number
9699AF
Product name
[4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]aceticacid
Packaging
5g
Price
$1442
Updated
2021/12/16
AK Scientific
Product number
9699AF
Product name
[4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]aceticacid
Packaging
250mg
Price
$166
Updated
2021/12/16
Ambeed
Product number
A120379
Product name
2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)aceticacid
Purity
97%
Packaging
250mg
Price
$208
Updated
2021/12/16
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2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid Chemical Properties,Usage,Production

Synthesis

944317-66-2

1255945-85-7

Step 3: Dissolve 2-fluoro-5-(ethyl formate)phenylboronic acid pinacol ester in a mixture of a solvent miscible with water (e.g., THF, methanol or acetone) and water. Lithium hydroxide (3.0 equiv) was added and the reaction mixture was stirred at room temperature. The progress of the reaction is monitored by TLC and LCMS until the starting material is essentially consumed (reaction time is typically 6-12 hours). Upon completion of the reaction, the THF was concentrated and separated by extraction with ethyl acetate and water. The organic layer was washed with water and the aqueous phases were combined. The washed aqueous phase is acidified with 2N HCl and extracted again with ethyl acetate. The ethyl acetate extracts were combined, dried with sodium sulfate and concentrated in vacuum to give the crude product. The crude product was sufficiently pure in most cases and could be used directly in the next step of the reaction. Reaction conditions: LiOH (3.0 equiv), THF:H2O (1:1), room temperature, 4 h. Yield 65%. Details of the synthesized compounds are given in Table 12.

References

[1] Patent: US2014/194383, 2014, A1. Location in patent: Paragraph 0387; 0392-0393

2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid Suppliers

China 24 India 1 United States 3 Global 28
Aladdin Scientific
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Synthonix Inc
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Combi-Blocks Inc.
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1255945-85-7, 2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acidRelated Search:

2-(5-bromopyridin-2-yl)acetic acid 2-(4-Bromophenyl)-2-oxoacetic acid

  • 2-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid
  • Benzeneacetic acid, 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • DYFNQNVMHCQXDI-UHFFFAOYSA-N
  • 1255945-85-7