ChemicalBook > CAS DataBase List > Methoxy-X04

Methoxy-X04

Product Name: Methoxy-X04
CAS No.: 863918-78-9
Chemical Name: Methoxy-X04
Synonyms: RMA-333;Methoxy-X04;Methoxy-X04, 10 mM in DMSO;MethoxyX04,Methoxy X04,Methoxy-X-04;Methoxy-X04, amyloid beta fluorescent marker;4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol;4,4'-((1E,1'E)-(2-Methoxy-1,4-phenylene)bis(ethene-2,1-diyl))diphenol;Phenol, 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis- (9CI);4-[(1E)-2-{4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-2-methoxyphenyl}ethenyl]phenol
CBNumber: CB93067560
Molecular Formula: C23H20O3
Formula Weight: 344.4031
MOL File: 863918-78-9.mol

Less

Methoxy-X04 Property

Boiling point:: 554.2±29.0 °C(Predicted)
Density: 1.244±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C,protect from light
solubility: Soluble in DMSO
form: crystalline solid
pka: 9.98±0.26(Predicted)
color: Yellow

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3861
Product name: Methoxy-X04
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $145.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3861
Product name: Methoxy-X04
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $739
Updated: 2025/07/31

Cayman Chemical

Product number: 20476
Product name: Methoxy-X04
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20476
Product name: Methoxy-X04
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 20476
Product name: Methoxy-X04
Purity: ≥95%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Less

Methoxy-X04 Chemical Properties,Usage,Production

Description

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid. It displays high in vitro binding affinity (K_i = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer''s disease. For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging. Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.

Uses

Methoxy-X04 is a small molecule Aβ-binding agent, which exhibits anti-amyloid effects.

in vivo

Methoxy-X04 (5-10 mg/kg, i.p., once time) differentiates individual plaques in PS1/APP mice within 30 to 60 min^[2].

storage

+4°C. Protect from light.

References

[1] WILLIAM E KLUNK. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.[J]. Journal of Neuropathology and Experimental Neurology, 2002, 61 9: 797-805. DOI: 10.1093/jnen/61.9.797
[2] STEFFEN BURGOLD. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks[J]. Acta Neuropathologica, 2010, 121 3: 327-335. DOI: 10.1007/s00401-010-0787-6

Methoxy-X04 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Methoxy-X04 Suppliers

China 74 United Kingdom 2 United States 7 Global 83

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10110
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Amel Pharmatech Corporation

Tel: 027-888-4366503
Fax: 888-502-1736
Email: sales@amelpharmatech.com
Country: China
ProdList: 5000
Advantage: 58

Hunan Huayi Zhide Pharmaceutical Technology Co., Ltd.

Tel: 17752881701
Email: 190060276@qq.com
Country: China
ProdList: 170
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4810
Advantage: 58

Hangzhou FuRun Pharmaceutical Technology Co., Ltd

Tel: 15658004993
Email: 1900830611@qq.com
Country: China
ProdList: 980
Advantage: 58

Hefei Mokai Pharmaceutical Technology Co., Ltd

Tel: 18130062233
Email: 3362556465@qq.com
Country: China
ProdList: 8100
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

NewCan Biotech Limited

Tel: +86-0571-86912261 +86-15658003402
Fax: 311113
Email: sales@newcanbio.com
Country: China
ProdList: 1391
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Changsha Yanzheng Biotechnology Co. LTD

Tel: 13975823787
Email: 277087306@qq.com
Country: China
ProdList: 88
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 9898
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Country: China
ProdList: 2993
Advantage: 58

Hubei Aiputi Bioengineering Co., Ltd.

Tel: 17762444226
Email: d17762444226@163.com
Country: China
ProdList: 2402
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-025-66113011 18626450290
Email: cb5@aikonchem.com
Country: China
ProdList: 10358
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 0731-13823398 15111215862
Email: 313359644@qq.com
Country: China
ProdList: 4161
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59101766 13125137661
Email: 2853877621@qq.com
Country: China
ProdList: 7975
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Taizhou Chuanxu Pharmaceutical Technology Co., Ltd.

Tel: 13000000000
Email: 974144639@qq.com
Country: China
ProdList: 9979
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 43339
Advantage: 58

Guangzhou Meijun Biotechnology Co., Ltd.

Tel: 18664742264
Country: CHINA
ProdList: 151
Advantage: 58

Sperui Technology (Guangzhou) Co., Ltd.

Tel: 18826050589
Country: CHINA
ProdList: 186
Advantage: 58

Guangzhou Tuoshan Biotechnology Co., Ltd.

Tel: 19928332050
Country: CHINA
ProdList: 161
Advantage: 58

Hangzhou Haofeng Biotechnology Co., Ltd.

Tel: 057186405477
Country: CHINA
ProdList: 184
Advantage: 58

Guangzhou Kangkaixin Biotechnology Co., Ltd.

Tel: 13760798286
Country: CHINA
ProdList: 188
Advantage: 58

Beijing Zhongcheng Jinnian Technology Co., Ltd.

Tel: 18510511586
Country: CHINA
ProdList: 159
Advantage: 58

Guangzhou Squirrel Biotechnology Co., Ltd.

Tel: 17765276361
Country: CHINA
ProdList: 109
Advantage: 58

Shanghai Hongmai Biotechnology Co., Ltd.

Tel: 400-920-5774
Country: CHINA
ProdList: 146
Advantage: 58

Guangzhou Chuangze Biotechnology Co., Ltd.

Tel: 18312220236
Country: CHINA
ProdList: 178
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Beijing Bai Ao Si Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yangmei@bioneeds.net
Country: CHINA
ProdList: 6999
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6793
Advantage: 58

863918-78-9, Methoxy-X04Related Search:

Methoxy-X04

4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol

MethoxyX04,Methoxy X04,Methoxy-X-04

Phenol, 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis- (9CI)

4,4'-((1E,1'E)-(2-Methoxy-1,4-phenylene)bis(ethene-2,1-diyl))diphenol

4-[(1E)-2-{4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-2-methoxyphenyl}ethenyl]phenol

Methoxy-X04, amyloid beta fluorescent marker

Methoxy-X04, 10 mM in DMSO

RMA-333

863918-78-9