ChemicalBook > CAS DataBase List > CREB inhibitor (666-15)

CREB inhibitor (666-15)

Product Name
CREB inhibitor (666-15)
CAS No.
1433286-70-4
Chemical Name
CREB inhibitor (666-15)
Synonyms
666-15;compound3i;CREB 666-15;CREB inhibitor;compound3i(666-15);CREB inhibitor (666-15);breast,666-15,Epigenetic Reader Domain,cancer,CREB,66615,666 15,inhibit,Inhibitor;3-(3-Aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride
CBNumber
CB93069852
Molecular Formula
C33H31Cl2N3O5
Formula Weight
620.53
MOL File
1433286-70-4.mol
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CREB inhibitor (666-15) Property

storage temp. 
Store at -20°C
solubility 
DMF: 5mg/mL; DMSO: 5mg/mL
form 
A solid
color 
White to off-white
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A616443
Product name
3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamideHydrochloride
Packaging
1mg
Price
$95
Updated
2021/12/16
TRC
Product number
A616443
Product name
3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamideHydrochloride
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-6499
Product name
CREB inhibitor (666-15)
Purity
99.63%
Packaging
25mg
Price
$552
Updated
2021/12/16
ChemScene
Product number
CS-6499
Product name
CREB inhibitor (666-15)
Purity
99.63%
Packaging
50mg
Price
$996
Updated
2021/12/16
ChemScene
Product number
CS-6499
Product name
CREB inhibitor (666-15)
Purity
99.63%
Packaging
5mg
Price
$156
Updated
2021/12/16
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CREB inhibitor (666-15) Chemical Properties,Usage,Production

Uses

3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide Hydrochloride has been identified as an antitumor agent.

Biological Activity

CREB inhibitor (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM. It also inhibits the growth of cancer cells without affecting normal cells.

in vitro

666-15 can effectively inhibit the growth of cancer cells. In MDA-MB-231 and MDA-MB-468 cells, the GI50 values of 666-15 were 73 nM and 46 nM, respectively. 666-15 also had strong activity in A549 and MCF-7 cells, with GI50 of 0.47 μM and 0.31 μM, respectively. 666-15 inhibits the transcriptional activity of CREB in live cells that do not depend on direct CREB or CBP binding reactions.

in vivo

In the in vivo MDA-MB-468 xenograft tumor model, 666-15 completely inhibited tumor growth without obvious toxicity. Intraperitoneal injection of 10 mg/kg of 666-15 in mice was well tolerated.

target

TargetValue
CREB
()		 81 nM

storage

Desiccate at RT

CREB inhibitor (666-15) Preparation Products And Raw materials

Raw materials

Preparation Products

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1433286-70-4, CREB inhibitor (666-15)Related Search:

D-RIBULOSE 1,5-DIPHOSPHATE BARIUM*HYDRAT E

  • CREB inhibitor (666-15)
  • 666-15
  • compound3i(666-15)
  • CREB inhibitor
  • compound3i
  • CREB 666-15
  • 3-(3-Aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride
  • breast,666-15,Epigenetic Reader Domain,cancer,CREB,66615,666 15,inhibit,Inhibitor
  • 1433286-70-4