ChemicalBook > CAS DataBase List > BP-1-102

BP-1-102

Product Name: BP-1-102
CAS No.: 1334493-07-0
Chemical Name: BP-1-102
Synonyms: BP-1-102;STAT3 Inhibitor XVIII;BP-1-102, 10 mM in DMSO;BP-1-102; BP1-102; BP 1-102.;STAT3 Inhibitor XVIII, BP-1-102;STAT3 INHIBITOR XVIII;BP1-102;BP 1-102;4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydr;4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid;BP-1-102,4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-hydroxy-
CBNumber: CB93069948
Molecular Formula: C29H27F5N2O6S
Formula Weight: 626.59
MOL File: 1334493-07-0.mol

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BP-1-102 Property

Boiling point:: 749.2±70.0 °C(Predicted)
Density: 1.474±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:15.0(Max Conc. mg/mL);23.9(Max Conc. mM)
form: A crystalline solid
pka: 3.15±0.10(Predicted)
color: White to off-white
InChIKey: WNVSFFVDMUSXSX-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=O)C=C1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28368
Product name: BP-1-102
Packaging: 5mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 28368
Product name: BP-1-102
Packaging: 50mg
Price: $722
Updated: 2024/03/01

Cayman Chemical

Product number: 28368
Product name: BP-1-102
Packaging: 10mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 28368
Product name: BP-1-102
Packaging: 25mg
Price: $452
Updated: 2024/03/01

TRC

Product number: B676715
Product name: BP1-102
Packaging: 10mg
Price: $920
Updated: 2021/12/16

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BP-1-102 Chemical Properties,Usage,Production

Uses

BP-1-102 is a potent and selective STAT3 inhibitor. STAT3 is a cytoplasmic transcription factor that induces the expression of genes related to tumorigenesis. BP 1-102 exhibits antitumor activity against Waldenstrom macroglobulinemia, a rare form of B cell non-Hodgkin lymphoma.

Biological Activity

Primary Target
Stat3

Synthesis

1334493-48-9

1334493-07-0

General method: Benzyl-protected salicylic acid (1 eq.) was dissolved in a stirred solvent mixture of methanol/tetrahydrofuran (1:1, v/v, 0.1 M). After thorough degassing, 10% palladium/carbon catalyst (10 mg/mmol) was cautiously added. The solution was bubbled with hydrogen gas for 5 minutes, followed by continuous stirring of the reaction under hydrogen atmosphere for 3 hours. Upon completion of the reaction, the hydrogen was removed, the palladium catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure.

in vivo

Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas^[2]. BP-1-102 is orally bioavailable and that the agent accumulates in tumor tissues at levels sufficient to inhibit aberrantly active Stat3 functions and inhibit tumor growth^[1].

IC 50

STAT3: 6.8 μM (IC₅₀)

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5605 - 5609
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 11, p. 1102 - 1107
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 18, p. 7190 - 7200

BP-1-102 Preparation Products And Raw materials

Raw materials

Preparation Products

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1334493-07-0, BP-1-102Related Search:

Epacadostat (INCB024360)

BP-1-102

4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydr

STAT3 Inhibitor XVIII, BP-1-102

BP-1-102; BP1-102; BP 1-102.

4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

STAT3 Inhibitor XVIII

STAT3 INHIBITOR XVIII;BP1-102;BP 1-102

Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-hydroxy-

BP-1-102,4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

BP-1-102, 10 mM in DMSO

1334493-07-0

C29H27F5N2O6S

API