1361-50-8
- Product Name
- 1361-50-8
- CAS No.
- 1361-51-9
- Chemical Name
- 1361-50-8
- Synonyms
- Taxine B;1361-50-8;Valine Impurity 64;Benzenepropanoic acid, β-(dimethylamino)-, (3S,4aR,5S,6R,11R,12R,12aR)-11-(acetyloxy)-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-5,6,12-trihydroxy-9,12a,13,13-tetramethyl-4-methylene-8-oxo-6,10-methanobenzocyclodecen-3-yl ester, (βS)-
- CBNumber
- CB93076485
- Molecular Formula
- C33H45NO8
- Formula Weight
- 583.7123
- MOL File
- 1361-51-9.mol
1361-50-8 Property
- Melting point:
- l13-5°C (approx.)
- Boiling point:
- 676.9±55.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- solubility
- Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.63±0.70(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
1361-50-8 Chemical Properties,Usage,Production
Description
A constituent of Taxus baccata, this alkaloid is amorphous and has [α]20D + 119° (CHC13). The hydrochloride is also amorphous with no definite melting point. The nitrate, however, can be crystallized from Et20-isopropanol, m.p. 190°C. The base yields a diacetyl derivative which, although amorphous when obtained from aqueous solution, m.p. 92°C, forms colourless crystals from EtOH, m.p. 161.5°C. This latter base has [α]20Do + 106.7° (c 2.0, CHC1 3) and gives a crystalline hydrochloride from EtOH containing solvent of crystallization, m.p. 168-l70°C; nitrate as colourless needles or plates from EtOH, m.p. 141.5°C and the methiodide, m.p. 197°C. The structure of the alkaloid is that of Taxine I (q.v.) minus two acetyl groups.
Uses
Taxine B is a toxic pyrrolizidine alkaloid obtained from rhodadendron and ragwort plants decomposition. An impurity in the biosynthesis of Paclitaxel (P132500)
References
Harrison, Scrowston, Lythgoe., 1. Chern. Soc., C, 1933 (1966)
1361-50-8 Preparation Products And Raw materials
Raw materials
Preparation Products
1361-50-8 Suppliers
- Tel
- --
- Fax
- --
- mktg@pharmaffiliates.com
- Country
- India
- ProdList
- 6739
- Advantage
- 58