tert-butyl 4-amino-1H-pyrazole-1-carboxylate
- Product Name
- tert-butyl 4-amino-1H-pyrazole-1-carboxylate
- CAS No.
- 1018446-95-1
- Chemical Name
- tert-butyl 4-amino-1H-pyrazole-1-carboxylate
- Synonyms
- 1-Boc-4-aminopyrazole;tert-butyl 4-aminopyrazole-1-carboxylate;tert-Butyl 4-amino-1H-pyrazol-1-carboxylate;tert-butyl 4-amino-1H-pyrazole-1-carboxylate;4-amino-pyrazole-1-carboxylic acid tert-butyl ester;tert-butyl 4-amino-1H-pyrazole-1-carboxylate - [B81113];1H-Pyrazole-1-carboxylic acid, 4-amino-, 1,1-dimethylethyl ester
- CBNumber
- CB93080299
- Molecular Formula
- C8H13N3O2
- Formula Weight
- 183.21
- MOL File
- 1018446-95-1.mol
tert-butyl 4-amino-1H-pyrazole-1-carboxylate Property
- Boiling point:
- 306.7±34.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 2.36±0.11(Predicted)
- Appearance
- Brown to reddish brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B750360
- Product name
- tert-Butyl4-Amino-1H-pyrazole-1-carboxylate
- Packaging
- 250mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 135394
- Product name
- tert-Butyl 4-amino-1H-pyrazole-1-carboxylate
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $1144
- Updated
- 2021/12/16
- Product number
- CM324870
- Product name
- tert-Butyl4-amino-1H-pyrazole-1-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $1450
- Updated
- 2021/12/16
- Product number
- A243534
- Product name
- tert-Butyl4-amino-1H-pyrazole-1-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $421
- Updated
- 2021/12/16
- Product number
- CD11365319
- Product name
- tert-Butyl4-amino-1H-pyrazole-1-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $550
- Updated
- 2021/12/16
tert-butyl 4-amino-1H-pyrazole-1-carboxylate Chemical Properties,Usage,Production
Synthesis
1018446-96-2
1018446-95-1
(c) Synthesis of tert-butyl 4-amino-1H-pyrazole-1-carboxylate (A55): tert-butyl 4-nitro-1H-pyrazole-1-carboxylate (A54, 3.70 g, 17.4 mmol) and 10% Pd/C (0.300 g) were suspended in EtOH (150 mL) and moistened with ~5% water. The reaction mixture was stirred for 20 h at room temperature under hydrogen (1 atm) atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with EtOAc (about 100 mL). The filtrate was concentrated under reduced pressure to afford tert-butyl 4-amino-1H-pyrazole-1-carboxylate (3.09 g, 97% yield) as a light brown solid.1H NMR (400 MHz, CDCl3) δ 7.54 (d, J = 0.6 Hz, 1H), 7.40 (d, J = 0.8 Hz, 1H), 3.10 (s, 2H), 1.62 (s, 9H). LCMS analysis: retention time (rt) 3.75 min; no product ions detected.
References
[1] Patent: WO2014/128465, 2014, A1. Location in patent: Page/Page column 79
[2] Patent: WO2008/139161, 2008, A1. Location in patent: Page/Page column 197
[3] Patent: WO2015/89337, 2015, A1. Location in patent: Paragraph 0211
[4] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 000128
[5] Patent: US2009/325956, 2009, A1. Location in patent: Page/Page column 38
tert-butyl 4-amino-1H-pyrazole-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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