3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile

Product Name: 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile
CAS No.: 134997-74-3
Chemical Name: 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile
Synonyms: 3-oxo-4H-1,4-benzoxazine-6-carbonitrile;3,4-Dihydro-3-oxo-2H-1,4-benzoxazine-6-carbonitrile;2H-1,4-Benzoxazine-6-carbonitrile, 3,4-dihydro-3-oxo-;3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile;3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile
CBNumber: CB93084297
Molecular Formula: C9H6N2O2
Formula Weight: 174.16
MOL File: 134997-74-3.mol

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3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Property

Melting point:: 106-108 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
Boiling point:: 403.2±45.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 11.77±0.20(Predicted)
color: Pale brown

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 4H48-1-TB
Product name: 3,4-Dihydro-3-oxo-2H-1,4-benzoxazine-6-carbonitrile
Purity: 95.0%
Packaging: 250mg
Price: $184
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0389431
Product name: 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-6-CARBONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $497.17
Updated: 2021/12/16

Matrix Scientific

Product number: 171547
Product name: 3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile
Purity: 95%
Packaging: 2.500g
Price: $1650
Updated: 2021/12/16

AK Scientific

Product number: 6262AA
Product name: 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile
Packaging: 10g
Price: $2642
Updated: 2021/12/16

J&W Pharmlab

Product number: 05R0931
Product name: 3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile
Purity: 97%
Packaging: 100mg
Price: $131
Updated: 2021/12/16

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3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Chemical Properties,Usage,Production

Synthesis

24036-52-0

557-21-1

134997-74-3

A degassed suspension was prepared from 6-bromo-2H-1,4-benzoxazin-3(4H)-one (8.39 g), zinc cyanide (3.46 g) and tetrakis(triphenylphosphine)palladium (2.13 g) in DMF (70 mL). The suspension was reacted in an oil bath at 80 °C with stirring overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into water (500 mL). The precipitate was collected by diafiltration, air dried and washed with pentane. The resulting solid was dissolved in a solvent mixture of dichloromethane/methanol (1:1), filtered through a pad of silica gel, and the filtrate was concentrated to give the yellow solid product 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile (5.68 g, 89% yield). Mass spectrometric detection showed [MH]+ = 175.

References

[1] Patent: WO2008/63667, 2008, A1. Location in patent: Page/Page column 69
[2] Patent: WO2008/63669, 2008, A1. Location in patent: Page/Page column 72
[3] Patent: WO2008/63671, 2008, A2. Location in patent: Page/Page column 174

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Suppliers

China 33 India 1 United States 3 Global 37

Shanghai Synthfine Chemical Co.,Ltd

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134997-74-3, 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrileRelated Search:

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