6-bromo-7-fluoroisatin

Product Name: 6-bromo-7-fluoroisatin
CAS No.: 1336963-95-1
Chemical Name: 6-bromo-7-fluoroisatin
Synonyms: 6-bromo-7-fluoroindoline-2,3-dione;EA105;6-bromo-7-fluoroisatin;6-Bromo-7-fluoro-1H-indole-2,3-dione;1H-Indole-2,3-dione, 6-bromo-7-fluoro-;6-bromo-7-fluoro-2,3-dihydro-1H-indole-2,3-dione;6-bromo-7-fluoro-2,3-dihydro-1H-indole-2,3-dione - [B31347]
CBNumber: CB93088260
Molecular Formula: C8H3BrFNO2
Formula Weight: 244.02
MOL File: 1336963-95-1.mol

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6-bromo-7-fluoroisatin Property

Density: 1.907±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.42±0.20(Predicted)
Appearance: Yellow to brown Solid
InChI: InChI=1S/C8H3BrFNO2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12/h1-2H,(H,11,12,13)
InChIKey: GVZVXBNHVMAAAK-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(Br)=C2F)C(=O)C1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B961600
Product name: 6-Bromo-7-fluoroindoline-2,3-dione
Packaging: 500mg
Price: $315
Updated: 2021/12/16

Ambeed

Product number: A749837
Product name: 6-Bromo-7-fluoroindoline-2,3-dione
Purity: 97%
Packaging: 100mg
Price: $58
Updated: 2021/12/16

Ambeed

Product number: A749837
Product name: 6-Bromo-7-fluoroindoline-2,3-dione
Purity: 97%
Packaging: 250mg
Price: $96
Updated: 2021/12/16

Ambeed

Product number: A749837
Product name: 6-Bromo-7-fluoroindoline-2,3-dione
Purity: 97%
Packaging: 1g
Price: $184
Updated: 2021/12/16

Chemcia Scientific

Product number: BB20-7271
Product name: 6-Bromo-7-fluoro-1H-indole-2,3-dione
Purity: 95%
Packaging: 1g
Price: $195
Updated: 2021/12/16

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6-bromo-7-fluoroisatin Chemical Properties,Usage,Production

Uses

6-?Bromo-?7-?fluoroindoline-?2,?3-?dione is a heterocyclic reagent used in the synthesis of electrophiles capable of targeting K-Ras oncogense in the treatment of cancer.

Synthesis

1336963-99-5

1336963-95-1

N-(3-bromo-2-fluorophenyl)-2-(hydroxyimino)acetamide (1.82 g, 7.03 mmol) was used as a raw material, which was slowly added to concentrated sulfuric acid (20 mL) at 60°C. Subsequently, the temperature of the reaction system was raised to 90°C and the reaction was maintained at this temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water. The precipitated yellow precipitate was collected by filtration and dried to give 6-bromo-7-fluorodihydroindole-2,3-dione (1.41 g, 82% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 11.75 (s, 1H), 7.39 (dd, J = 5.7,7.9 Hz, 1H), 7.31 (d, J = 8.2 Hz, 1H).

References

[1] Patent: WO2015/54572, 2015, A1. Location in patent: Page/Page column 253
[2] Patent: WO2017/87528, 2017, A1. Location in patent: Page/Page column 180; 181
[3] Patent: WO2017/58915, 2017, A1. Location in patent: Page/Page column 102
[4] Patent: US2018/15087, 2018, A1. Location in patent: Paragraph 0320
[5] Patent: WO2011/119704, 2011, A1. Location in patent: Page/Page column 40

6-bromo-7-fluoroisatin Preparation Products And Raw materials

Raw materials

Preparation Products

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6-bromo-7-fluoroisatin Suppliers

China 71 United States 3 Global 74

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1336963-95-1, 6-bromo-7-fluoroisatinRelated Search:

6-bromo-7-fluoroisatin

6-bromo-7-fluoroindoline-2,3-dione

6-bromo-7-fluoro-2,3-dihydro-1H-indole-2,3-dione

6-Bromo-7-fluoro-1H-indole-2,3-dione

1H-Indole-2,3-dione, 6-bromo-7-fluoro-

EA105

6-bromo-7-fluoro-2,3-dihydro-1H-indole-2,3-dione - [B31347]

1336963-95-1