ChemicalBook > CAS DataBase List > (R)-(+)-1-(4-Methylphenyl)ethylamine
(R)-(+)-1-(4-Methylphenyl)ethylamine
- Product Name
- (R)-(+)-1-(4-Methylphenyl)ethylamine
- CAS No.
- 4187-38-6
- Chemical Name
- (R)-(+)-1-(4-Methylphenyl)ethylamine
- Synonyms
- Tolylethylamine;(R)-1-P-TOLYLETHANAMINE;Methyl phenyl-ethylamine;(+)-p,α-Dimethylbenzylamine;alpha,4-dimethylbenzylamine;(R)-α,p-Dimethylbenzylamine;(R)-1-(p-tolyl)ethan-1-amine;(R)-(+)-1-(P-TOLYL)ETHYLAMINE;(R)-(+)-A-(P-TOLYL)ETHYLAMINE;(R)-(+)-4-(1-AMINOETHYL)TOLUENE
- CBNumber
- CB9311444
- Molecular Formula
- C9H13N
- Formula Weight
- 135.21
- MOL File
- 4187-38-6.mol
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(R)-(+)-1-(4-Methylphenyl)ethylamine Property
- Melting point:
- <-20°C
- Boiling point:
- 205 °C (lit.)
- alpha
- 37 º (NEAT)
- Density
- 0.919 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.521(lit.)
- Flash point:
- 180 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.20±0.10(Predicted)
- Specific Gravity
- 0.919
- optical activity
- [α]20/D +37°, neat
- Sensitive
- Air Sensitive
- BRN
- 3195425
- CAS DataBase Reference
- 4187-38-6(CAS DataBase Reference)
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Safety
- Hazard Codes
- C
- Risk Statements
- 20/21/22-34
- Safety Statements
- 16-26-27-36/37/39-45
- RIDADR
- UN 2619 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 2921490090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 726664
- Product name
- (R)-(+)-α,4-Dimethylbenzylamine
- Purity
- ChiPros
- Packaging
- 5g
- Price
- $104
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 405248
- Product name
- (R)-(+)-α,4-Dimethylbenzylamine
- Purity
- 98%
- Packaging
- 1g
- Price
- $122
- Updated
- 2023/06/20
TCI Chemical
- Product number
- T1380
- Product name
- (R)-(+)-1-(p-Tolyl)ethylamine
- Purity
- >98.0%(GC)
- Packaging
- 1mL
- Price
- $99
- Updated
- 2021/12/16
Alfa Aesar
- Product number
- L16328
- Product name
- (R)-(+)-1-(4-Methylphenyl)ethylamine, ChiPros 98+%
- Purity
- ee 98%
- Packaging
- 5g
- Price
- $71
- Updated
- 2021/12/16
Alfa Aesar
- Product number
- L16328
- Product name
- (R)-(+)-1-(4-Methylphenyl)ethylamine, ChiPros 98+%
- Purity
- ee 98%
- Packaging
- 1g
- Price
- $34.9
- Updated
- 2021/12/16
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(R)-(+)-1-(4-Methylphenyl)ethylamine Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liquid
Uses
(R)-(+)-α,4-Dimethylbenzylamine can be used as a chiral salt of keto acid, employed in the solid-state photolysis studies of α-mesitylacetophenone derivatives.
Application
(R)-(+)-α,4-Dimethylbenzylamine reacts with 1,5-difluoro-2,4-dinitrobenzene (DFDNB) to form a chiral derivative reagent(CDR) via substitution of one fluorine atom.
General Description
(R)-(+)-α,4-Dimethylbenzylamine is a chiral amine.
Synthesis
(R)-(+)-1-(4-methylphenyl)ethylamine was synthesized via a series of chemical reactions with (R)-N-[1-(4-methylphenyl)ethyl]acetamide. The steps are as follows:
1 g of the compound obtained in the previous stage will be used. 2 g of n-butanol was added, 0.63 g of potassium hydroxide was added, and the temperature was raised to 100 ° C. After 24 hours of heat preservation, cool down to 10 to 20 ℃. After adding water and stirring for 0.5 hours, the mixture was allowed to stand for separation, and the organic layer was concentrated to n-butanol, and then subjected to vacuum distillation (80-100 ℃ packed column) to obtain (R)-1-(4-methylphenyl)ethylamine 0.63 g. The yield was 82%, the HPLC purity was 96.3%, and the enantiomer was 0.8%.
structure and hydrogen bonding
(R)-(+)-1-(4-Methylphenyl)ethylamine is a chiral molecule studied in the context of crystallographic analysis and optimization. Through X-ray diffraction analysis, the crystal structure of (R)-(+)-1-(4-Methylphenyl)ethylamine was determined, revealing the presence of a significant hydrogen bond between the amine group and one of the carbonyl groups. This hydrogen bond plays a crucial role in stabilizing the (R)-(+)-1-(4-Methylphenyl)ethylamine molecule, which is a recurring pattern observed in structurally similar compounds. Furthermore, the (S)-(+)-enantiomer of (R)-(+)-1-(4-Methylphenyl)ethylamine was synthesized using an enantiopure precursor, establishing an efficient method to obtain this desired form of the molecule.
(R)-(+)-1-(4-Methylphenyl)ethylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-(+)-1-(4-Methylphenyl)ethylamine manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- (R)-1-(p-Tolyl)ethanamine 4187-38-6
- Price
- US $1.00-35.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-07-30
Career Henan Chemical Co
- Product
- (R)-(+)-1-(4-Methylphenyl)ethylamine 4187-38-6
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-12
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