ABT-639

ChemicalBook > CAS DataBase List > ABT-639

Product Name: ABT-639
CAS No.: 1235560-28-7
Chemical Name: ABT-639
Synonyms: ABT-639;ABT-693;CS-2286;ABT-639 (ABT639;ABT-639, CID 46851313;Calcium Channel,Ca channels,Ca2+ channels,inhibit,Inhibitor,ABT639,ABT-639;(R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide;4-CHLORO-2-FLURO-N-(2-FLUOROPHENYL)-5-[(8AR)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-2(1H)-YLCARBONYL]BENZENESULFONAMIDE;4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide;Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-
CBNumber: CB93121075
Molecular Formula: C20H20ClF2N3O3S
Formula Weight: 455.91
MOL File: 1235560-28-7.mol

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ABT-639 Property

Boiling point:: 612.2±65.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:9.71(Max Conc. mg/mL);21.3(Max Conc. mM)
DMF:14.0(Max Conc. mg/mL);30.71(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.09(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.1(Max Conc. mM)
form: A solid
pka: 6.80±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28742
Product name: ABT-639
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 28742
Product name: ABT-639
Packaging: 25mg
Price: $586
Updated: 2024/03/01

Cayman Chemical

Product number: 28742
Product name: ABT-639
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 28742
Product name: ABT-639
Packaging: 10mg
Price: $257
Updated: 2024/03/01

Tocris

Product number: 6770
Product name: ABT639
Purity: ≥98%(HPLC)
Packaging: 10
Price: $220
Updated: 2021/12/16

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ABT-639 Chemical Properties,Usage,Production

Description

ABT-639 is a T-type calcium channel blocker. It inhibits inactivated-state Ca_v3.2 channels with an IC₅₀ value of 2.3 μM and inactivated-state Ca_v3.1 and Ca_v3.3 channels by 50 and 39%, respectively, when used at a concentration of 10 μM. ABT-639 selectively inhibits inactivated-state T-type calcium currents over resting-state currents in rat dorsal root ganglion (DRG) neurons (IC₅₀s = 7.6 and >30 μM, respectively). It reverses the hind limb grip force deficit in a rat model of osteoarthritic pain induced by monoiodoacetic acid (MIA; ED₅₀ = 2 mg/kg). ABT-639 also increases the paw withdrawal threshold in rat spinal nerve ligation (SNL) and chronic constriction injury (CCI) models of neuropathic pain in a dose-dependent manner and attenuates cold allodynia in the CCI rat model when administered at doses greater than or equal to 3 mg/kg.

Description

ABT-639 is a selective T-type calcium channel blocker with efficacy in a wide range of preclinical models of nociceptive and neuropathic pain.ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat.

storage

Store at -20°C

References

Zhang, Q., et al. "Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639."Acs Medicinal Chemistry Letters6.6(2015):150429091057009.
Serra, J, et al. "Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. " Pain 156.11(2015):2175.
http://www.medkoo.com/products/6989

ABT-639 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ABT-639 manufacturers

Career Henan Chemical Co

Product: 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl]benzenesulfonamide 1235560-28-7
Price: US $1.00/KG
Min. Order: 1g
Purity: Min98% HPLC
Supply Ability: g/kg /ton
Release date: 2019-12-20

1235560-28-7, ABT-639Related Search:

CC-223

ABT-639

4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide

4-CHLORO-2-FLURO-N-(2-FLUOROPHENYL)-5-[(8AR)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-2(1H)-YLCARBONYL]BENZENESULFONAMIDE

ABT-639, CID 46851313

(R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

ABT-639 (ABT639

CS-2286

ABT-693

Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-

Calcium Channel,Ca channels,Ca2+ channels,inhibit,Inhibitor,ABT639,ABT-639

1235560-28-7

C20H20ClF2N3O3S