N-Acetyl-Calicheamicin
- Product Name
- N-Acetyl-Calicheamicin
- CAS No.
- 108212-76-6
- Chemical Name
- N-Acetyl-Calicheamicin
- Synonyms
- N-Acetyl-Calicheamicin;N-acetyl-calicheamidn y1;N-Acetyl-Calicheamicin g1;N-acetylcalicheamicin γ1;N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ);N-Acetyl-Calicheamicin γ|||N-Acetyl-γ-calicheamicin;Carbamic acid, [(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-β-D-glucopyranosyl]oxy]-1-hydr...
- CBNumber
- CB93121121
- Molecular Formula
- C57H76IN3O22S4
- Formula Weight
- 1410.38
- MOL File
- 108212-76-6.mol
N-Acetyl-Calicheamicin Property
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 7.13±0.60(Predicted)
- color
- White to off-white
- InChIKey
- WPDOZYZAJKUVRZ-VEKKAAIHNA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H310Fatal in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H330Fatal if inhaled
H335May cause respiratory irritation
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P350IF ON SKIN: Gently wash with plenty of soap and water.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P361Remove/Take off immediately all contaminated clothing.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-5417
- Product name
- N-Acetyl-Calicheamicin
- Purity
- >98.0%
- Packaging
- 1mg
- Price
- $2160
- Updated
- 2021/12/16
- Product number
- CS-5417
- Product name
- N-Acetyl-Calicheamicin
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $7200
- Updated
- 2021/12/16
- Product number
- CD31004636
- Product name
- N-Acetyl-Calicheamicin
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $4167
- Updated
- 2021/12/16
N-Acetyl-Calicheamicin Chemical Properties,Usage,Production
Description
N-Acetyl-Calicheamicin is a potent enediyne antitumor antibiotic.
Uses
N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC[1].
References
[1] K C Nicolaou, et al. Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2107042118. DOI:10.1073/pnas.2107042118
[2] Breanna S Vollmar, et al. Calicheamicin Antibody-Drug Conjugates with Improved Properties. Mol Cancer Ther. 2021 Jun;20(6):1112-1120. DOI:10.1158/1535-7163.MCT-20-0035
N-Acetyl-Calicheamicin Preparation Products And Raw materials
Raw materials
Preparation Products
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