4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine
- Product Name
- 4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine
- CAS No.
- 1621375-32-3
- Chemical Name
- 4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine
- Synonyms
- 187295;4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine;4-(4-(2,4-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine;Morpholine, 4-[4-(2,4-dibromo-1H-imidazol-1-yl)-2-thiazolyl]-
- CBNumber
- CB93122173
- Molecular Formula
- C10H10Br2N4OS
- Formula Weight
- 394.09
- MOL File
- 1621375-32-3.mol
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Property
- Boiling point:
- 551.4±60.0 °C(Predicted)
- Density
- 2.12±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (317.19 mM; Need ultrasonic)
- form
- Solid
- pka
- 2.01±0.50(Predicted)
- color
- White to off-white
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Chemical Properties,Usage,Production
Biological Activity
VPC-14449 is a potent and selective inhibitor of the DNA-binding domain of the androgen receptor (AR-DBD), with IC50 of 0.34 μM for full-length human AR. VPC-14449 reduces the ability of full-length AR as well as AR variants to interact with chromatin. VPC-14449 can be used for the research of prostate cancer[1][2]. VPC-14449 (0.01-100 μM; 24 h) inhibits AR-transcriptional activity and cell viability in LNCaP, C4-2, MR49F, and 22Rv1 cells[2].VPC-14449 (0.01-100 μM; 24 h) dose-dependently inhibits the transiently expressed full-length human AR in PC3 cells (IC50=0.34 μM) without affecting AR protein expression[1]. VPC-14449 (100 mg/kg; i.p. twice daily for 4 weeks) reduces tumor volume and abolishes PSA production with no decrease in body weight over a total duration 4 weeks in LNCaP xenograft model[1].
References
[1]. Dalal K, et, al. Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. J Biol Chem. 2014 Sep 19;289(38):26417-26429. [2]. Dalal K, et, al. Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions. Mol Cancer Ther. 2017 Oct;16(10):2281-2291.
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Suppliers
- Tel
- 0510-83588313-811 18800520310;
- sales@chemshuttle.com
- Country
- China
- ProdList
- 3000
- Advantage
- 62
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9804
- Advantage
- 58
- Tel
- 19906241957
- Fax
- -
- 1557216087@qq.com
- Country
- China
- ProdList
- 1781
- Advantage
- 55
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24644
- Advantage
- 58
- Tel
- 13421666688 13421666688
- 664261110@qq.com
- Country
- China
- ProdList
- 410
- Advantage
- 58
- Tel
- 0513-66337626 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 5127
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12000
- Advantage
- 58