ChemicalBook > CAS DataBase List > AS1842856

AS1842856

Product Name
AS1842856
CAS No.
836620-48-5
Chemical Name
AS1842856
Synonyms
CS-2538;AS1842856;AS 1842856;AS-1842856;5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-
CBNumber
CB93122441
Molecular Formula
C18H22FN3O3
Formula Weight
347.38
MOL File
836620-48-5.mol
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AS1842856 Property

Boiling point:
587.3±50.0 °C(Predicted)
Density 
1.370±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO:5.0(Max Conc. mg/mL);14.39(Max Conc. mM)
form 
A crystalline solid
pka
6.47±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16761
Product name
AS-1842856
Purity
≥98%
Packaging
1mg
Price
$31
Updated
2024/03/01
Cayman Chemical
Product number
16761
Product name
AS-1842856
Purity
≥98%
Packaging
5mg
Price
$77
Updated
2024/03/01
Cayman Chemical
Product number
16761
Product name
AS-1842856
Purity
≥98%
Packaging
10mg
Price
$108
Updated
2024/03/01
Tocris
Product number
4265
Product name
AS1842856
Purity
≥98%(HPLC)
Packaging
10
Price
$95
Updated
2021/12/16
TRC
Product number
A790073
Product name
AS1842856
Packaging
10mg
Price
$95
Updated
2021/12/16
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AS1842856 Chemical Properties,Usage,Production

Description

AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1; IC50 = 33 nM in HepG2 cells). Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). AS-1842856 also inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes.,

Uses

AS 1842856 is a novel FoxO1 antagonist with anti-obesity effects.

Definition

ChEBI: AS1842856 is a quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. It has a role as a hypoglycemic agent, an anti-obesity agent, an autophagy inhibitor, an antineoplastic agent, an apoptosis inducer and a forkhead box protein O1 inhibitor. It is a quinolinemonocarboxylic acid, a quinolone, an organofluorine compound, a primary amino compound, a secondary amino compound and a tertiary amino compound.

storage

Store at -20°C

AS1842856 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS1842856 Suppliers

China 71 United States 9 Global 80
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from AS1842856 manufacturers

Career Henan Chemical Co
Product
AS1842856 836620-48-5
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

836620-48-5, AS1842856Related Search:

Butyl ethyl ether 1-Cyclohexylethanol

  • AS1842856
  • 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
  • CS-2538
  • AS 1842856;AS-1842856
  • 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
  • 3-Quinolinecarboxylic acid, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-
  • 836620-48-5