ALS-8176 (active form)

Product Name: ALS-8176 (active form)
CAS No.: 1445379-92-9
Chemical Name: ALS-8176 (active form)
Synonyms: ALS-8112;ALS-8112 (ALS 8112;ALS-8176 (active form);4'-chloromethyl-2'-deoxy-2'-fluorocytidine;Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-;4-Amino-1-[5-chloro-2,5-dideoxy-2-fluoro-4-(hydroxymethyl)-a-L-lyxofuranosyl]-2(1H)-pyrimidinone;4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
CBNumber: CB93122926
Molecular Formula: C10H13ClFN3O4
Formula Weight: 293.68
MOL File: 1445379-92-9.mol

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ALS-8176 (active form) Property

Boiling point:: 532.8±60.0 °C(Predicted)
Density: 1.78±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 47 mg/mL (160.04 mM)
form: Solid
pka: 12.47±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5472
Product name: ALS-8112
Purity: 99.97%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5472
Product name: ALS-8112
Purity: 99.97%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5472
Product name: ALS-8112
Purity: 99.97%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-5472
Product name: ALS-8112
Purity: 99.97%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-5472
Product name: ALS-8112
Purity: 99.97%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

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ALS-8176 (active form) Chemical Properties,Usage,Production

Uses

ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.

References

[1] Wang G, et al. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58(4):1862-78. DOI:10.1021/jm5017279
[2] Jordan PC, et al. Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase. ACS Chem Biol. 2017 Jan 20;12(1):83-91. DOI:10.1021/acschembio.6b00788
[3] DeVincenzo JP, et al. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. N Engl J Med. 2015 Nov 19;373(21):2048-58. DOI:10.1056/NEJMoa1413275
[4] Deval J, et al. Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate. PLoS Pathog. 2015 Jun 22;11(6):e1004995. DOI:10.1371/journal.ppat.1004995

ALS-8176 (active form) Preparation Products And Raw materials

Raw materials

Preparation Products

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ALS-8176 (active form) Suppliers

China 24 United States 5 Global 29

BOC Sciences

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1445379-92-9, ALS-8176 (active form)Related Search:

ALS-8176 (active form)

4'-chloromethyl-2'-deoxy-2'-fluorocytidine

ALS-8112

ALS-8112 (ALS 8112

4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-Amino-1-[5-chloro-2,5-dideoxy-2-fluoro-4-(hydroxymethyl)-a-L-lyxofuranosyl]-2(1H)-pyrimidinone

Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-

1445379-92-9

C10H13ClFN3O4