ChemicalBook > CAS DataBase List > AZ6102
AZ6102
- Product Name
- AZ6102
- CAS No.
- 1645286-75-4
- Chemical Name
- AZ6102
- Synonyms
- AZ6102;CS-2332;AZ6102 >=98% (HPLC);AZ-6102;AZ6102;AZ 6102;AZ 6102,PARP,AZ-6102,Inhibitor,poly ADP ribose polymerase,inhibit,AZ6102;2-(4-(6-(cis-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one;2-(4-(6-((3S,5R)-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3Hpyrrolo[2,3-d]pyrimidin-4(7H)-one;rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-, rel-
- CBNumber
- CB93126696
- Molecular Formula
- C25H28N6O
- Formula Weight
- 428.53
- MOL File
- 1645286-75-4.mol
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AZ6102 Property
- Boiling point:
- 657.6±65.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 8.70±0.60(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 19898
- Product name
- AZ 6102
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19898
- Product name
- AZ 6102
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19898
- Product name
- AZ 6102
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $231
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19898
- Product name
- AZ 6102
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $530
- Updated
- 2024/03/01
Tocris
- Product number
- 5775
- Product name
- AZ6102
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $221
- Updated
- 2021/12/16
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AZ6102 Chemical Properties,Usage,Production
Uses
AZ 6102 is a a potent TNKS1/2 inhibitor that has 100-fold selectivity against other poly(ADP-ribose) polymerase (PARP) family enzymes.
Biological Activity
az6102 is a tnks1/2 inhibitor.inhibition of the poly(adp-ribose) polymerase (parp) catalytic domain of the tankyrases (tnks1 and tnks2) is reported to inhibit the wnt pathway by increasing stabilization of axin. the canonical wnt pathway plays a critical role in adult tissue homeostasis, embryonic development, as well as cancer.
in vitro
az6102 was identified as a potent tnks1/2 inhibitor with 100-fold selectivity against other parp family enzymes including parps 1, 2, and 6. in addition, az6102 showed a 5 nm ic50 against wnt pathway in dld-1 cells [1].
in vivo
in animal study, az6102 was intravenously dosed to nude mice at 25 mg/kg, and the results showed that az6102 had a clearance of 24 ml/min·kg and a half-life of 4 h. the bioavailability of az6102 in mouse and rat was only moderate at 12% and 18%, respectively. in addition, az6102 was used as an intravenous probe compound to evaluate the in vivo effects of tnks1/2 inhibition on normal tissue and tumor xenografts, however, the results of such experiments have not be released so far [1].
IC 50
1 and 3 nm for tnks2 and tnks1, respectively
storage
Store at -20°C
References
[1] j. w. johannes, l. almeida, b. barlaam,et al.pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathways inhibitors suitable for in vivopharmacology. acs med. chem. lett. 6, 254-259 (2015).
AZ6102 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from AZ6102 manufacturers
PNP Biotech Co. Ltd
- Product
- AZ6102 1645286-75-4
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%-99%
- Supply Ability
- Inquiry
- Release date
- 2022-09-16