ONO-4059 (hydrochloride)

ChemicalBook > CAS DataBase List > ONO-4059 (hydrochloride)

ONO-4059 (hydrochloride)

Product Name: ONO-4059 (hydrochloride)
CAS No.: 1439901-97-9
Chemical Name: ONO-4059 (hydrochloride)
Synonyms: ON 0459;ON-0459;ONO-WG-307;ONO-4059 HCl;ON 0459;ON-0459;Tirabrutinib HCl;ONO-4059(HCl salt);ONO-4059 (GS-4059);GS-4059 (hydrochloride);ONO-4059 (hydrochloride)
CBNumber: CB93126702
Molecular Formula: C25H23ClN6O3
Formula Weight: 490.95
MOL File: 1439901-97-9.mol

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ONO-4059 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5637
Product name: Tirabrutinib(hydrochloride)
Purity: 98.80%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-5637
Product name: Tirabrutinib(hydrochloride)
Purity: 98.80%
Packaging: 10mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-5637
Product name: Tirabrutinib(hydrochloride)
Purity: 98.80%
Packaging: 25mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-5637
Product name: Tirabrutinib(hydrochloride)
Purity: 98.80%
Packaging: 50mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-5637
Product name: Tirabrutinib(hydrochloride)
Purity: 98.80%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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ONO-4059 (hydrochloride) Chemical Properties,Usage,Production

Uses

ONO-4059 hydrochloride is a potent orally active BTK (Bruton's tyrosine kinase) inhibitor, IC50: 2.2nM.It is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration,it covalently binds to BTK within B cells,thereby preventing B-cell receptor signaling and impeding B-cell development.

Biological Activity

Tirabrutinib Hydrochloride (ONO-4059, GS-4059) is a highly potent and selective BTK inhibitor with IC50 of 2.2 nM.

in vitro

Compared with Lck, Fyn, LynA, ONO-4059 is more selective for BTK, and only inhibits anti-IgM-induced B cell activation in a concentration-dependent manner, but not anti-CD3/CD28-induced Activation of human PBMCs to T lymphocytes. ONO/GS-4059 inhibited cell proliferation in some malignant B cells, but also in the nanomolar concentration range, induced the classical apoptotic response of TMD8 cells.

in vivo

In the CIA mouse model, ONO-4059 exerted its curative effect by inhibiting the production of inflammatory chemokines and cytokines such as IL-6, IL-8, TNFalpha, etc. in monocytes, accompanied by cartilage erosion, bone damage, vascular Recession of nebula formation. In preclinical animal models and clinical CLL and NHL patients, ONO-4059 has antitumor activity, good safety and long-lasting efficacy.

target

Target	Value
BTK	2.2 nM

ONO-4059 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ONO-4059 (hydrochloride) manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: ONO4059 hydrochloride 1439901-97-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: ONO4059 hydrochloride 1439901-97-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-11-26

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: ONO4059 hydrochloride 1439901-97-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-11-26

1439901-97-9, ONO-4059 (hydrochloride)Related Search:

Btk Kinase inhibitor

ONO-4059 (hydrochloride)

ON 0459

ON 0459;ON-0459

ON-0459

TIRABRUTINIB (ONO-4059) HYDROCHLORIDE

GS-4059 (hydrochloride)

Tirabrutinib hydrochloride

TIRABRUTINIB HYDROCHLORIDE;GS-4059 (HYDROCHLORIDE)

Tirabrutinib HCl

ONO-4059 HCL; ONO4059; ONO 4059; ONO-4059; GS 4059; GS-4059; GS4059; ONO-WG-307; TIRABRUTINIB

ONO-WG-307

(R)-6-amino-9-(1-but-2-ynoylpyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one

ONO-4059(GS4059) hydrochloride

ONO-4059 HCl

(R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride

(R)-6-amino-9-(1-but-2-ynoylpyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one HCl salt

ONO-4059(HCl salt)

Tirabrutinib (ONO-4059) HCl

tirabrutinib(GS-4059/ONO-4059) hydrochloride

B cells,GS-4059,haematological malignancies,Bruton tyrosine kinase,GS4059,PCNSL,Tirabrutinib,ONO4059,GS 4059,ONO 4059,Inhibitor,ONO-4059,autoimmune disorders,Tirabrutinib hydrochloride,Apoptosis,Btk,inhibit

ONO-4059 (GS-4059)

1439901-97-9