CBR-5884

Product Name: CBR-5884
CAS No.: 681159-27-3
Chemical Name: CBR-5884
Synonyms: CBR-5884;CBR 5884;CBR5884;CBR 5884,inhibit,CBR-5884,Inhibitor,CBR5884;ethyl 4-(cyanosulfanyl)-5-(furan-2-amido)-3-methylthiophene-2-carboxylate;Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate;Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate;2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester
CBNumber: CB93128968
Molecular Formula: C14H12N2O4S2
Formula Weight: 336.39
MOL File: 681159-27-3.mol

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CBR-5884 Property

Boiling point:: 378.1±42.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 50 mg/ml) or in DMF (up to 50 mg/ml).
form: paste
pka: 11.25±0.70(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1656
Product name: CBR-5884
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1656
Product name: CBR-5884
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $424
Updated: 2023/06/20

Cayman Chemical

Product number: 19236
Product name: CBR-5884
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19236
Product name: CBR-5884
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 19236
Product name: CBR-5884
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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CBR-5884 Chemical Properties,Usage,Production

Description

CBR-5884 (681159-27-3) is a potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM.1?The action of PHGDH is the first committed step of serine biosynthesis2?and certain cancer cells overexpress PHGDH3. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents.1

Uses

CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.

Biochem/physiol Actions

CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) that inhibits proliferation of melanoma and breast cancer lines. CBR-5884 inhibits de novo serine synthesis in in cancer cells.

References

1) Mullarky?et al. (2016),?Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers; Proc. Natl. Acad. Sci. USA,?113?1778 2) Snell et al.?(1986),?The duality of pathways for serine biosynthesis is a fallacy; Trends Biochem. Sci.,?11(6)?241 3) DeNicola?et al. (2015),?NFR2 regulates serine biosynthesis in non-small cell lung cancer; Nat. Genet.,?47?1475

CBR-5884 Preparation Products And Raw materials

Raw materials

Preparation Products

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CBR-5884 Suppliers

China 53 India 1 United Kingdom 1 United States 10 Global 65

Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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TargetMol Chemicals Inc.

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Aladdin Scientific

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ApexBio Technology

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BOC Sciences

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Focus Biomolecules

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Cayman Chemical Company

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Axon Medchem LLC

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681159-27-3, CBR-5884Related Search:

Troglitazone Geldanamycin Imatinib mesylate Cantharidin

Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate

CBR 5884;CBR5884

ethyl 4-(cyanosulfanyl)-5-(furan-2-amido)-3-methylthiophene-2-carboxylate

CBR-5884

2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester

CBR 5884,inhibit,CBR-5884,Inhibitor,CBR5884

Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate

681159-27-3