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AS-2444697

Product Name
AS-2444697
CAS No.
1287665-60-4
Chemical Name
AS-2444697
Synonyms
AS-244469;AS-2444697;AS-2444697 HC;AS-2444697 HCl;AS2444697 >=98% (HPLC);AS-2444697 (hydrochloride);FGNHLIIFEDYNFZ-UHFFFAOYSA-N;N-(3-CARBAMOYL-1-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-PYRAZOL-4-YL)-2-(2-METHYLPYRIDIN-4-YL)OXAZOLE-4-CARBOXAMIDE HCL;N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride;N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
CBNumber
CB93133027
Molecular Formula
C19H21ClN6O4
Formula Weight
432.86084
MOL File
1287665-60-4.mol
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AS-2444697 Property

storage temp. 
2-8°C
solubility 
DMSO:16.83(Max Conc. mg/mL);38.88(Max Conc. mM)
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1643
Product name
AS2444697
Purity
≥98% (HPLC)
Packaging
5MG
Price
$131
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1643
Product name
AS2444697
Purity
≥98% (HPLC)
Packaging
25MG
Price
$424
Updated
2023/06/20
Cayman Chemical
Product number
29505
Product name
AS-2444697 (hydrochloride)
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
29505
Product name
AS-2444697 (hydrochloride)
Packaging
10mg
Price
$249
Updated
2024/03/01
Cayman Chemical
Product number
29505
Product name
AS-2444697 (hydrochloride)
Packaging
5mg
Price
$133
Updated
2024/03/01
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AS-2444697 Chemical Properties,Usage,Production

Description

AS-2444697 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4; IC50 = 21 nM). It is greater than 30-fold selective for IRAK4 over a panel of 146 kinases, but is less than 10-fold selective over PDGFRα, PDGFRβ, TrkA, TrkC, CLK1, Itk, and FLT3. AS-2444697 inhibits IL-1β-induced IL-6 production and LPS-induced TNF-α production in cellular assays (IC50s = 250 and 47 nM, respectively). It is efficacious in rat models of adjuvant- and collagen-induced arthritis (ED50s = 2.7 and 1.6 mg/kg, respectively). AS-2444697 (0.3-3 mg/kg, twice daily) reduces urinary protein excretion, the development of interstitial fibrosis and glomerulosclerosis, and renal mRNA expression of genes encoding IL-1β, IL-6, TNF-α, and chemokine (C-C motif) ligand 2 (CCL2) without affecting blood pressure in the 5/6 nephrectomized rat model of chronic kidney disease.

Uses

AS2444697 has been used as an interleukin-1R-associated kinase 4 (IRAK4) inhibitor to study the role of interleukin (IL)-1/IL-33 signaling in the development of endometriosis using a mouse model of endometriosis. It has also been used to study its dose-dependent effect on the C-X-C motif chemokine ligand 8 (CXCL8) gene expression

Biochem/physiol Actions

AS2444697 is a potent and selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4) that suppresses the progression of chronic renal failure via anti-inflammatory action.

storage

Desiccate at RT

AS-2444697 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS-2444697 Suppliers

China 43 United Kingdom 1 United States 6 Global 50
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1287665-60-4, AS-2444697Related Search:


  • AS-2444697
  • N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride
  • AS-244469
  • N-(3-CARBAMOYL-1-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-PYRAZOL-4-YL)-2-(2-METHYLPYRIDIN-4-YL)OXAZOLE-4-CARBOXAMIDE HCL
  • 4-Oxazolecarboxamide, N-[3-(aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-, hydrochloride (1:1)
  • AS-2444697 HCl
  • FGNHLIIFEDYNFZ-UHFFFAOYSA-N
  • N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
  • AS-2444697 (hydrochloride)
  • AS2444697 >=98% (HPLC)
  • AS-2444697 HC
  • IL-1R associated kinase,IRAK-4,anti-inflammatory,IRAK,AS-2444697,inhibit,AS2444697,AS 2444697,renoprotective,Inhibitor,Interleukin-1 receptor associated kinase
  • 1287665-60-4