ChemicalBook > CAS DataBase List > IMR-1A
IMR-1A
- Product Name
- IMR-1A
- CAS No.
- 331862-41-0
- Chemical Name
- IMR-1A
- Synonyms
- IMR-1A;IMR-1A, >98%;IMR1A;IMR 1A;IMR-1A;Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite;2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
- CBNumber
- CB93133188
- Molecular Formula
- C13H11NO5S2
- Formula Weight
- 325.36
- MOL File
- 331862-41-0.mol
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IMR-1A Property
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM) - pka
- 3.10±0.10(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-5752
- Product name
- IMR-1A
- Purity
- 98.23%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5752
- Product name
- IMR-1A
- Purity
- 98.23%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5752
- Product name
- IMR-1A
- Purity
- 98.23%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5752
- Product name
- IMR-1A
- Purity
- 98.23%
- Packaging
- 100mg
- Price
- $2520
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN18826
- Product name
- IMR-1A
- Packaging
- 100mg
- Price
- $2016
- Updated
- 2021/12/16
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IMR-1A Chemical Properties,Usage,Production
Biological Activity
IMR-1A is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. It has antitumor activity.
in vivo
IMR-1A (2 mg/kg (iv) and 100 mg/kg (ip)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/ 2) of 2.22 h following a single iv administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.
| Animal Model: | Male C57 BL/6 mice |
| Dosage: | 2 mg/kg (iv) and 100 mg/kg (ip) |
| Iv and ip | |
| Result: | Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single iv administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration. |
target
| Target | Value |
| Notch (Cell-free assay) | 0.5 μM |
| Notch (Cell-free assay) | 2.9 μM(Kd) |