4-(DIFLUOROMETHOXY)ACETOPHENONE
- Product Name
- 4-(DIFLUOROMETHOXY)ACETOPHENONE
- CAS No.
- 83882-67-1
- Chemical Name
- 4-(DIFLUOROMETHOXY)ACETOPHENONE
- Synonyms
- AKOS B016264;AKOS BBS-00000545;ART-CHEM-BB B016264;4-(DIFLUOROMETHOXY)ACETOPHENONE;4'-(Difluoromethoxy)acetophenone;4'-(Difluoromethoxy)acetophenone98%;4'-(Difluoromethoxy)acetophenone >4'-(Difluoromethoxy)acetophenone 98%;1-(4-DIFLUOROMETHOXY-PHENYL)-ETHANONE;Ethanone, 1-[4-(difluoromethoxy)phenyl]-
- CBNumber
- CB9313514
- Molecular Formula
- C9H8F2O2
- Formula Weight
- 186.16
- MOL File
- 83882-67-1.mol
4-(DIFLUOROMETHOXY)ACETOPHENONE Property
- Melting point:
- 18-19°C
- Boiling point:
- 70-72°C 0,5mm
- Density
- 1.191±0.06 g/cm3(Predicted)
- refractive index
- 1.4930 to 1.4970
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Light orange to Yellow to Green
- λmax
- 252nm(EtOH)(lit.)
- CAS DataBase Reference
- 83882-67-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D4760
- Product name
- 4'-(Difluoromethoxy)acetophenone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- D4760
- Product name
- 4'-(Difluoromethoxy)acetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $242
- Updated
- 2025/07/31
- Product number
- D447708
- Product name
- 4-(Difluoromethoxy)acetophenone
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D447708
- Product name
- 4-(Difluoromethoxy)acetophenone
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- W8682
- Product name
- 4'-(Difluoromethoxy)acetophenone
- Packaging
- 10g
- Price
- $208
- Updated
- 2021/12/16
4-(DIFLUOROMETHOXY)ACETOPHENONE Chemical Properties,Usage,Production
Chemical Reactivity
4-(DIFLUOROMETHOXY)ACETOPHENONE is a chemical compound that contains the difluoromethoxy group. It has been shown to be a nitrogen-containing heterocycle, which makes it an important part of many pyridine derivatives. The cyclic molecule is also known as 1,2-difluoroethanone.
Synthesis
1895-39-2
99-93-4
83882-67-1
To a stirred solution of 4-hydroxyacetophenone (5.0 g, 36.76 mmol) in N,N-dimethylformamide (DMF, 50 mL) was added sodium 2-chloro-2,2-difluoroacetate (6.2 g, 40.44 mmol) followed by sodium hydroxide (NaOH, 1.76 g, 44.11 mmol). The reaction mixture was stirred at 100 °C for 14 hours. After completion of the reaction, the mixture was diluted with cold water and the product was extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a 20-30% ethyl acetate/hexane solvent mixture to afford the target compound 1-(4-difluoromethoxyphenyl)ethanone (3.5 g, 51.0% yield) as a colorless liquid.1H NMR (400 MHz, DMSO-d6): δ 8.05-8.01 (m, 2H), 7.59-7.22 (m 3H), 2.50 (s, 3H); LC-MS: m/z 187.0 [M+H]+.
References
[1] Patent: WO2018/165520, 2018, A1. Location in patent: Page/Page column 215-216
4-(DIFLUOROMETHOXY)ACETOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
4-(DIFLUOROMETHOXY)ACETOPHENONE Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- 021-64968085,64968086-5815,5812; 13472757003
- Fax
- +86 21 64968087
- xiaoxia.zeng@rainbowpharma.cn
- Country
- China
- ProdList
- 961
- Advantage
- 65
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 027-8866 0053/88660577/88660578
- Fax
- 027-8899 1911
- Country
- China
- ProdList
- 1073
- Advantage
- 55
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80