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FK-506-13C-d2

Product Name
FK-506-13C-d2
CAS No.
1356841-89-8
Chemical Name
FK-506-13C-d2
Synonyms
Tacrolimus-13C;13C, D2-Tacrolimus;TACROLIMUS (13C, 99%;Tacrolimus-13C;Tacrolimus-13C, D2 (major);Tacrolimus-13C,D2 solution;D2, 98%) 100 UG/ML IN ACETONITRILE;Methadone Hydrochloride Impurity 9;FK-506-13C,D2 (Major) (Tacrolimus) (>FK-506-13C,D2 (Major) (Tacrolimus)(>85%)
CBNumber
CB93141783
Molecular Formula
C44H67D2NO12
Formula Weight
807.039483556
MOL File
1356841-89-8.mol
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FK-506-13C-d2 Property

storage temp. 
-70°C
solubility 
Chloroform: Slightly Soluble,Methanol: Slightly Soluble
form 
A solid
color 
White to yellow
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Safety

RIDADR 
UN 1648 3 / PGII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22178
Product name
FK-506-13C-d2
Purity
≥99% deuterated forms (d<sub>1</sub>-d<sub>2</sub>); ≤1% d<sub>0</sub>
Packaging
500 μg
Price
$520
Updated
2024/03/01
Cayman Chemical
Product number
22178
Product name
FK-506-13C-d2
Purity
≥99% deuterated forms (d1-d2); ≤1% d0
Packaging
1mg
Price
$863
Updated
2022/04/27
TRC
Product number
F370002
Product name
FK-506-13C,D2(Major)(Tacrolimus)(>85%)
Packaging
2.5mg
Price
$1850
Updated
2021/12/16
AK Scientific
Product number
2276EL
Product name
(1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-(3,3-Dideuterio(313C)prop-2-enyl)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
Packaging
1mg
Price
$1178
Updated
2021/12/16
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FK-506-13C-d2 Chemical Properties,Usage,Production

Description

FK-506-13C-d2 contains two deuterium atoms located on the carbon-13 bond. It is intended for use as an internal standard for the quantification of FK-506 by GC- or LC-MS. FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation. The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors. In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3 receptors which can be disrupted by FK-506, thereby rendering the receptors “leaky” to Ca2+.

Uses

A labelled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. A representative lot contained a distribution of 20% d-1, 40% d-2 and 20% d-3.

General Description

This stable-labeled internal standard is suited for quantitation of tacrolimus by LC/MS or GC/MS for clinical toxicology, therapeutic drug monitoring, or isotope dilution methods. Tacrolimus, also known as FK-506 or fujimycin, is an immunosuppressive drug marketed as Prograf, Advagraf, and Protopic usually used to prevent rejection of organ transplants and treatment of eczema. Use of a stable-labeled analog of tacrolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.

IC 50

Macrolide

References

[1] SCHREIBER S L. Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands[J]. Science, 1991, 251 4991. DOI: 10.1126/science.1702904
[2] DUMONT F J. FK506, an immunosuppressant targeting calcineurin function.[J]. Current medicinal chemistry, 2000, 7 7: 731-748. DOI: 10.2174/0929867003374723
[3] S H SNYDER. Neural actions of immunophilin ligands.[J]. Trends in pharmacological sciences, 1998, 19 1: 21-26. DOI: 10.1016/s0165-6147(97)01146-2

FK-506-13C-d2 Preparation Products And Raw materials

Raw materials

Preparation Products

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FK-506-13C-d2 Suppliers

China 33 India 3 United States 5 Global 41
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
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50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Artis Biotech Co. Ltd.
Tel
028-67271278 18628360895
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
1960
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
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58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-025-85560043 17301488900
Fax
025-85563444
Email
info@synzest.com
Country
China
ProdList
9286
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
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58
QUALITY CONTROL SOLUTIONS LTD.
Tel
+86-0755-66853366 +86-13670046396
Email
export03@qcsrm.com
Country
China
ProdList
24342
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58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
18351873721
Email
helen.zhang@synzest.com
Country
China
ProdList
8295
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58

1356841-89-8, FK-506-13C-d2Related Search:


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