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FK-506-13C-d2

Product Name
FK-506-13C-d2
CAS No.
1356841-89-8
Chemical Name
FK-506-13C-d2
Synonyms
TACROLIMUS (13C, 99%;Tacrolimus-13C;Tacrolimus-13C, D2 (major);Tacrolimus-13C,D2 solution;D2, 98%) 100 UG/ML IN ACETONITRILE;Methadone Hydrochloride Impurity 9;FK-506-13C,D2 (Major) (Tacrolimus) (>FK-506-13C,D2 (Major) (Tacrolimus)(>85%);Fujimycin-13C,D2 Tacrolimus-13C D2 FK-506-13C,D2;Tacrolimus 13CD2Q: What is Tacrolimus 13CD2 Q: What is the CAS Number of Tacrolimus 13CD2 Q: What is the storage condition of Tacrolimus 13CD2 Q: What are the applications of Tacrolimus 13CD2
CBNumber
CB93141783
Molecular Formula
C44H67D2NO12
Formula Weight
807.039483556
MOL File
1356841-89-8.mol
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FK-506-13C-d2 Property

storage temp. 
-70°C
solubility 
Chloroform: Slightly Soluble,Methanol: Slightly Soluble
form 
A solid
color 
White to yellow
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Safety

RIDADR 
UN 1648 3 / PGII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22178
Product name
FK-506-13C-d2
Purity
≥99% deuterated forms (d<sub>1</sub>-d<sub>2</sub>); ≤1% d<sub>0</sub>
Packaging
500 μg
Price
$520
Updated
2024/03/01
Cayman Chemical
Product number
22178
Product name
FK-506-13C-d2
Purity
≥99% deuterated forms (d1-d2); ≤1% d0
Packaging
1mg
Price
$863
Updated
2022/04/27
TRC
Product number
F370002
Product name
FK-506-13C,D2(Major)(Tacrolimus)(>85%)
Packaging
2.5mg
Price
$1850
Updated
2021/12/16
AK Scientific
Product number
2276EL
Product name
(1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-(3,3-Dideuterio(313C)prop-2-enyl)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
Packaging
1mg
Price
$1178
Updated
2021/12/16
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FK-506-13C-d2 Chemical Properties,Usage,Production

Description

FK-506-13C-d2 contains two deuterium atoms located on the carbon-13 bond. It is intended for use as an internal standard for the quantification of FK-506 by GC- or LC-MS. FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation. The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors. In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3 receptors which can be disrupted by FK-506, thereby rendering the receptors “leaky” to Ca2+.

Uses

A labelled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. A representative lot contained a distribution of 20% d-1, 40% d-2 and 20% d-3.

General Description

This stable-labeled internal standard is suited for quantitation of tacrolimus by LC/MS or GC/MS for clinical toxicology, therapeutic drug monitoring, or isotope dilution methods. Tacrolimus, also known as FK-506 or fujimycin, is an immunosuppressive drug marketed as Prograf, Advagraf, and Protopic usually used to prevent rejection of organ transplants and treatment of eczema. Use of a stable-labeled analog of tacrolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.

FK-506-13C-d2 Preparation Products And Raw materials

Raw materials

Preparation Products

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FK-506-13C-d2 Suppliers

China 23 India 3 United States 5 Global 31
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Cambridge Isotope Laboratories, Inc.
Tel
--
Fax
--
Email
cilsales@isotope.com
Country
United States
ProdList
6598
Advantage
79
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

1356841-89-8, FK-506-13C-d2Related Search:


  • (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-<sup>13</sup>C-d<sub>2</sub>)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
  • Tacrolimus-<sup>13</sup>C
  • Tacrolimus-13C,D2 solution
  • TACROLIMUS (13C, 99%
  • D2, 98%) 100 UG/ML IN ACETONITRILE
  • FK-506-13C,D2 (Major) (Tacrolimus) (&gt
  • (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-13C-d2)-
  • FK-506-13C,D2 (Major) (Tacrolimus)(>85%)
  • Tacrolimus 13CD2Q: What is Tacrolimus 13CD2 Q: What is the CAS Number of Tacrolimus 13CD2 Q: What is the storage condition of Tacrolimus 13CD2 Q: What are the applications of Tacrolimus 13CD2
  • Fujimycin-13C,D2 Tacrolimus-13C D2 FK-506-13C,D2
  • Tacrolimus-13C, D2 (major)
  • Methadone Hydrochloride Impurity 9
  • (1R,9S,12S,13R,14S,17S,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-[(3-13C,3,3-2H?)prop-2-en-1-yl]-11,28-dioxa-4-azatricyclo[22.3.1.0?,?]octacos-18-ene-2,3,10,16-tetrone
  • 1356841-89-8
  • C44H67D2NO12
  • C43CH67D2NO12