2-Chloro-4-cyanophenylboronic Acid Pinacol Ester
- Product Name
- 2-Chloro-4-cyanophenylboronic Acid Pinacol Ester
- CAS No.
- 945391-06-0
- Chemical Name
- 2-Chloro-4-cyanophenylboronic Acid Pinacol Ester
- Synonyms
- 2-Chloro-4-cyanophenylboronic Acid Pinacol Ester;2-Chloro-4-cyanobenzeneboronic acid pinacol ester;3-chloro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile;2-(2-chloro-4-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;Benzonitrile, 3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-carbonitrile
- CBNumber
- CB93144779
- Molecular Formula
- C13H15BClNO2
- Formula Weight
- 263.53
- MOL File
- 945391-06-0.mol
2-Chloro-4-cyanophenylboronic Acid Pinacol Ester Property
- Melting point:
- 137.6-143.2 °C
- Boiling point:
- 362.8±32.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8660-B-02
- Product name
- 2-Chloro-4-cyanophenylboronic acid, pinacol ester
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- 1710DJ
- Product name
- 3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
- Packaging
- 1g
- Price
- $357
- Updated
- 2021/12/16
- Product number
- 8660-B-02
- Product name
- 2-Chloro-4-cyanophenylboronic acid, pinacol ester
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- 8660-B-02
- Product name
- 2-Chloro-4-cyanophenylboronic acid, pinacol ester
- Packaging
- 5G
- Price
- $1991
- Updated
- 2021/12/16
- Product number
- CM219310
- Product name
- 3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
2-Chloro-4-cyanophenylboronic Acid Pinacol Ester Chemical Properties,Usage,Production
Synthesis
154607-01-9
73183-34-3
945391-06-0
Bis(pinacolato)diboron (391 mg, 1.54 mmol), potassium acetate (412 mg, 4.5 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (102 mg, 0.14 mmol) were sequentially added to the reaction flask under nitrogen atmosphere. A solution of 2-chloro-4-bromobenzonitrile (300 mg, 1.4 mmol) in dioxane (15 mL) was then added. The reaction mixture was stirred at 80 °C for 12 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and the filter cake was washed with ethyl acetate (50 mL). The filtrate was concentrated under reduced pressure and the resulting residue was purified by preparative thin layer chromatography on silica gel to afford the white solid product 3-chloro-4-pinacolboronate benzonitrile (73 mg, 20% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 7.78 (d, J = 7.6 Hz, 1H), 7.62 (d, J = 1.2 Hz, 1H), 7.52 (dd, J = 7.6 Hz, 1.2 Hz, 1H), 1.37 (s, 12H) ppm.
References
[1] Patent: EP3275867, 2018, A1. Location in patent: Paragraph 0206; 0207
2-Chloro-4-cyanophenylboronic Acid Pinacol Ester Preparation Products And Raw materials
Raw materials
Preparation Products
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