ChemicalBook > CAS DataBase List > 1,7-Naphthyridin-8(7H)-one, 3-bromo-
1,7-Naphthyridin-8(7H)-one, 3-bromo-
- Product Name
- 1,7-Naphthyridin-8(7H)-one, 3-bromo-
- CAS No.
- 1375301-90-8
- Chemical Name
- 1,7-Naphthyridin-8(7H)-one, 3-bromo-
- Synonyms
- 7-naphthyridin-8(7H)-one;3-bromo-7H-[1,7]naphthyridin-8-one;3-Bromo-1,7-naphthyridin-8(7H)-one;1,7-Naphthyridin-8(7H)-one, 3-bromo-;3-bromo-7,8-dihydro-1,7-naphthyridin-8-one;3-bromo-1,7-naphthyridin-8-ol, 3-Bromo-1,7-naphthyridin-8(7H)-one
- CBNumber
- CB93144911
- Molecular Formula
- C8H5BrN2O
- Formula Weight
- 225.04
- MOL File
- 1375301-90-8.mol
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1,7-Naphthyridin-8(7H)-one, 3-bromo- Property
- Boiling point:
- 468.9±45.0 °C(Predicted)
- Density
- 1.711±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.80±0.20(Predicted)
- Appearance
- Off-white to brown Solid
- InChI
- InChI=1S/C8H5BrN2O/c9-6-3-5-1-2-10-8(12)7(5)11-4-6/h1-4H,(H,10,12)
- InChIKey
- GUOAFNIATRDFCL-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CNC2=O)C=C(Br)C=1
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Safety
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TRC
- Product number
- B606855
- Product name
- 3-bromo-1,7-naphthyridin-8-ol
- Packaging
- 25mg
- Price
- $285
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR500038
- Product name
- 3-Bromo-1,7-naphthyridin-8(7H)-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $77
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR500038
- Product name
- 3-Bromo-1,7-naphthyridin-8(7H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $198
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11269562
- Product name
- 3-Bromo-1,7-naphthyridin-8(7H)-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $550
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11269562
- Product name
- 3-Bromo-1,7-naphthyridin-8(7H)-one
- Purity
- 97%
- Packaging
- 10g
- Price
- $916
- Updated
- 2021/12/16
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1,7-Naphthyridin-8(7H)-one, 3-bromo- Chemical Properties,Usage,Production
Synthesis
1429870-16-5
1375301-90-8
5-Bromo-3-methylpyridine-2-carboxylic acid 1-dimethylaminomethyl-(E)-imide (2.5 g, 9.25 mmol) was used as starting material and dissolved in tetrahydrofuran (THF, 20 mL). A solution of potassium tert-butanolate (KOtBu, 1.565 g, 13.05 mmol) in THF (30 mL) was added dropwise under stirring. The reaction mixture was heated to reflux, maintained for 3 h and then cooled to room temperature. The pH of the reaction mixture was adjusted to 7 using concentrated hydrochloric acid (HCl). subsequently, the reaction mixture was concentrated to give a brown solid. This solid was washed with water (10 mL) and collected by filtration to afford the target product 3-bromo-1,7-naphthyridin-8-(7H)-one (2 g, 8 mmol). The product was analyzed by high performance liquid chromatography (HPLC) with a retention time (RtH9) of 0.56 min; electrospray ionization mass spectrometry (ESIMS) showed [M + H]+ peaks of 224.8 and 226.8 (containing 1 bromine atom); and the chemical shifts of nuclear magnetic resonance hydrogen spectra (1H-NMR, 400 MHz, DMSO-d6) were δ11.9 (s, 1H), 8.85 (s, 1H), 8.50 (s, 1H), 7.43 (d, 1H), 6.67 (d, 1H).
References
[1] Patent: WO2013/54291, 2013, A1. Location in patent: Page/Page column 77
1,7-Naphthyridin-8(7H)-one, 3-bromo- Preparation Products And Raw materials
Raw materials
Preparation Products
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