SCH 529074
- Product Name
- SCH 529074
- CAS No.
- 922150-11-6
- Chemical Name
- SCH 529074
- Synonyms
- SCH 529074;N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine;N1-(2-((4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine;1,3-Propanediamine, N3-[2-[[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-
- CBNumber
- CB93146379
- Molecular Formula
- C31H36Cl2N6
- Formula Weight
- 563.56
- MOL File
- 922150-11-6.mol
SCH 529074 Property
- Boiling point:
- 640.3±55.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml
- form
- A crystalline solid
- pka
- 9.44±0.28(Predicted)
N-Bromosuccinimide Price
- Product number
- 21552
- Product name
- SCH 529074
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21552
- Product name
- SCH 529074
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 21552
- Product name
- SCH 529074
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 21552
- Product name
- SCH 529074
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 4240
- Product name
- SCH529074
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $710
- Updated
- 2021/12/16
SCH 529074 Chemical Properties,Usage,Production
Description
SCH 529074 is a small molecule activator of p53, a tumor suppressor that is mutated or non-functional in 50% of human tumors. SCH 529074 restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift assay with Kd values of 0.6740 and 0.4313, respectively. It also stimulates DNA binding activity and prevents human double minute-2 (Hdm-2) ubiquitination of wild-type p53 in vitro. SCH 29074 reduces proliferation of tumor cell lines with mutant and wild-type p53 (EC50s = 400-3,700 nM), with the p53 mutant cell lines being the most sensitive. In vivo, SCH 529074 reduces tumor growth in a DLD-1 human colorectal cancer xenograft model in mice in a dose-dependent manner.
Uses
SCH 529074 is a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquination of wild type p53.
SCH 529074 Preparation Products And Raw materials
Raw materials
Preparation Products
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