3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid

Application Safely

Product Name: 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid
CAS No.: 20170-32-5
Chemical Name: 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid
Synonyms: 3,5-Di-tert-Butyl-4-hydroxyhydrocinnamic acid;3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLPROPIONIC ACID;3,5-Di-tert-butyl-4-hydroxybenzenepropionic acid;COX-1-IN-3;Fenozan acid;Irganox 1310;Antioxidant 1310;CHEMBRDG-BB 5229970;Propofol Related Compound 4;Zoledronic Acid Impurity 18
CBNumber: CB9315215
Molecular Formula: C17H26O3
Formula Weight: 278.39
MOL File: 20170-32-5.mol

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3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid Property

Melting point:: 172-174°C
Boiling point:: 364.3±37.0 °C(Predicted)
Density: 1.049±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 4.79±0.10(Predicted)
color: White to Off-White
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C17H26O3/c1-16(2,3)12-9-11(7-8-14(18)19)10-13(15(12)20)17(4,5)6/h9-10,20H,7-8H2,1-6H3,(H,18,19)
InChIKey: WPMYUUITDBHVQZ-UHFFFAOYSA-N
SMILES: C1(CCC(O)=O)=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1
CAS DataBase Reference: 20170-32-5(CAS DataBase Reference)
EPA Substance Registry System: 3,5-Di-tert-butyl-4-hydroxyhydocinnamic acid (20170-32-5)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
TSCA: Yes
HazardClass: IRRITANT
HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3452
Product name: 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic Acid
Packaging: 5G
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: D3452
Product name: 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic Acid
Packaging: 25G
Price: $89
Updated: 2025/07/31

TRC

Product number: D417555
Product name: 3,5-Di-tert-butyl-4-hydroxyphenylpropionicAcid
Packaging: 100g
Price: $820
Updated: 2021/12/16

TRC

Product number: D417555
Product name: 3,5-Di-tert-butyl-4-hydroxyphenylpropionicAcid
Packaging: 25g
Price: $275
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2729-1-82
Product name: 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid
Purity: 97%
Packaging: 500g
Price: $1052
Updated: 2021/12/16

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3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid Chemical Properties,Usage,Production

Application

One important application of 3-(3, 5-tert-butyl-4-hydroxyphenyl) propionic acid is in the synthesis of antioxidant. Most widespread stabilizers of phenolic structure are derivatives of a methyl ester 3-(3’,5’-di-tert.buyil-4’-hylroxyphenyl)-propionic acid, productions which are based on ester exchanges polyatomic alcohols. To the most significant is pentaeritril-tetrakis-3-(3’,5’-di-tert.buyil-4’- hylroxyphenyl)-propionate.
From the beginning of works on synthesis of derivatives of a methyl ester 3-(3’,5’-di-tert.buyil-4’-hylroxyphenyl)- propionic acid on the present are executed a series of basic researches on catalysis and technology.
And in the present work 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-propionic acid can be used as antioxidant group to modify esters. This kind of esters is useful in many fields, such as lubricating oil and cutting compound, because of two important functions (antioxidant and lubricant) in the same compound.

Safely

The toxicity of 3-(3,5-di-tert-butyl-4- hydroxyphenyl)propanoic acid, esters with C13-C15 branched and linear alcohols has been tested by EFSA. And this scientific opinion of EFSA deals with the risk assessment of the additive, 3-(3,5-di-tert-butyl-4- hydroxyphenyl)propanoic acid, esters with C13-C15 branched and linear alcohols, CAS No. 171090- 93-0, REF. No. 47060 for which the CEF Panel concluded that there is no safety concern for the consumer if the substance is used only in polyolefins in contact with foods other than fatty/highalcoholic and dairy products and its migration does not exceed 0.05 mg/kg food.

Uses

It is employed as an active pharmaceutical intermediate.

Synthesis

6386-38-5

20170-32-5

Under nitrogen protection, 117 g (0.4 mol) of methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate and 126.6 g of anhydrous methanol were added to the reactor and heated to reflux. Subsequently, 120 mL of 30% aqueous NaOH solution was added slowly dropwise and the reaction was kept for 2 hours. Upon completion of the reaction, 80 ml of 10 wt% HCl solution was added for neutralization, stirred and cooled to room temperature. The reaction mixture was filtered and the filter cake was washed with deionized water to neutral. Finally, the filter cake was dried at 110 °C for 4 h to give 115 g of the white solid product 3,5-di-tert-butyl-4-hydroxybenzenepropanoic acid (A1).

References

[1] Patent: US4713475, 1987, A
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982, vol. 31, # 7, p. 1417 - 1420
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982, # 7, p. 1594 - 1597
[4] Patent: CN104211616, 2016, B. Location in patent: Paragraph 0064-0066

3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

antioxidant 1024 Antioxidant 1010

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3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid Suppliers

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View Lastest Price from 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid manufacturers

Qingdao Truelight functional Material Technology Co., Ltd.

Product: 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid 20170-32-5
Price: US $200.00/KG
Min. Order: 1000KG
Purity: 98
Supply Ability: 1000m.t per year
Release date: 2022-09-23

Career Henan Chemical Co

Product: 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid 20170-32-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

20170-32-5, 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acidRelated Search:

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3,5-Di-tert-butyl-4-hydroxybenzenepropionic acid

3,5-Di-tert-Butyl-4-hydroxyhydrocinnamic acid

Fenozan acid

3,5-Di-tert-butyl-4-hydroxyphenylpropionic acid, 98%, 98%

3-[3,5-di(tert-butyl)-4-hydroxyphenyl]propanoic acid (en)

3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid 98%

3,5-di-tert-butyl-4-hydroxyphenylpropionic acid (3,5-DTBHA)

Dibutylhydroxyphenylpropionicacid

3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionsure

CHEMBRDG-BB 5229970

3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLPROPIONIC ACID

4-HYDROXY-3,5-DI-TERT-BUTYLPHENYLPROPIONIC ACID

3-[3,5-DI(TERT-BUTYL)-4-HYDROXYPHENYL]PROPANOIC ACID

3-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-PROPIONIC ACID

3,5-bis(1,1-dimethylethyl)-4-hydroxy-benzenepropanoicaci

3,5-bis(1,1-Dimethylethyl)-4-hydroxybenzenepropanoicacid

3,5-bis(1,1-dimethylethyl)-4-hydroxy-Benzenepropanoicacid

3,5-bis(1,1-dimethyethyl)-4-hydroxyBenzenepropanoic acid

3-(4-Hydroxy-3,5-di-tert-butylphenyl)propionic acid

Propofol Related Compound 4

Antioxidant 1310

3,5-Di-tert-butyl-4-hydroxyphenylpropionicaci

3-(3',5'-Di-tert-Butyl-4'-hydroxyphenyl)propionic acid

Zoledronic Acid Impurity 18

COX-1-IN-3

3,5-Di-tert-butyl-4-hydroxybenzenepropanoic acid

Irganox 1310

20170-32-5

C17H26O3

Carboxylic

Aromatic Propionic Acids