(3S,5S)-Atorvastatin (sodium salt)

Product Name: (3S,5S)-Atorvastatin (sodium salt)
CAS No.: 1428118-38-0
Chemical Name: (3S,5S)-Atorvastatin (sodium salt)
Synonyms: Atorvastatin EP Impurity E Sodium Salt;Atorvastatin impurity 32/(3S,5S)-Atorvastatin Sodium Salt/Atorvastatin EP Impurity E Sodium Salt/(3S,5S)-Atorvastatin Calcium Salt/((3S,5S)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate) Sodium Sal;Atorvastatin impurity 32/(3S,5S)-Atorvastatin Sodium Salt/Atorvastatin EP Impurity E Sodium Salt/(3S,5S)-Atorvastatin Calcium Salt/((3S,5S)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate) Sodium Salt
CBNumber: CB93152420
Molecular Formula: C33H36FN2NaO5
Formula Weight: 582.65
MOL File: 1428118-38-0.mol

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(3S,5S)-Atorvastatin (sodium salt) Property

storage temp.: Store at -20°C
solubility: ≤0.5mg/ml in ethanol;15mg/ml in DMSO;25mg/ml in dimethyl formamide
form: crystalline solid
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18465
Product name: (3S,5S)-Atorvastatin (sodium salt)
Purity: ≥98%
Packaging: 1mg
Price: $74
Updated: 2024/03/01

Cayman Chemical

Product number: 18465
Product name: (3S,5S)-Atorvastatin (sodium salt)
Purity: ≥98%
Packaging: 5mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 18465
Product name: (3S,5S)-Atorvastatin (sodium salt)
Purity: ≥98%
Packaging: 10mg
Price: $583
Updated: 2024/03/01

TRC

Product number: A791735
Product name: (3S,5S)-AtorvastatinSodiumSalt
Packaging: 10mg
Price: $590
Updated: 2021/12/16

ApexBio Technology

Product number: C4030
Product name: (3S,5S)-Atorvastatin(sodiumsalt)
Packaging: 10mg
Price: $666
Updated: 2021/12/16

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(3S,5S)-Atorvastatin (sodium salt) Chemical Properties,Usage,Production

Uses

(3S,5S)-Atorvastatin Sodium Salt (Atorvastatin EP Impurity E) is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Biological Activity

atorvastatin exists in four optical forms. the (3r, 5r)-atorvastatin enantiomer displays the greatest activity against hmg-coa reductase. (3s,5s)-atorvastatin is an enantiomer of atorvastatin with little or no inhibitory activity against hmg-coa reductase [1]. atorvastatin is a synthetic hmg-coa reductase inhibitor implicated in lowering plasma cholesterol levels by inhibiting endogenous cholesterol synthesis. atorvastatin also reduces triglyceride levels through an as yet unproven mechanism [2]. in various trials in patients with hypercholesterolaemia, atorvastatin produced greater reductions in total cholesterol, apolipoprotein b, ldl-cholesterol and triglyceride levels. in patients with primary hypercholesterolaemia, atorvastatin in combination with colestipol produced significant reductions in ldl-cholesterol levels and smaller reductions in triglyceride levels than atorvastatin monotherapy [2].

References

[1] kocarek t a, dahn m s, cai h, et al. regulation of cyp2b6 and cyp3a expression by hydroxymethylglutaryl coenzyme a inhibitors in primary cultured human hepatocytes[j]. drug metabolism and disposition, 2002, 30(12): 1400-1405.
[2] lea a p, mctavish d. atorvastatin[j]. drugs, 1997, 53(5): 828-847.

(3S,5S)-Atorvastatin (sodium salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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(3S,5S)-Atorvastatin (sodium salt) Suppliers

China 9 India 2 United States 2 Global 13

Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Haohong Scientific Co., Ltd.

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Suzhou ARTK Medchem Co., Ltd.

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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1428118-38-0, (3S,5S)-Atorvastatin (sodium salt)Related Search:

Atorvastatin impurity 32/(3S,5S)-Atorvastatin Sodium Salt/Atorvastatin EP Impurity E Sodium Salt/(3S,5S)-Atorvastatin Calcium Salt/((3S,5S)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate) Sodium Sal

Atorvastatin impurity 32/(3S,5S)-Atorvastatin Sodium Salt/Atorvastatin EP Impurity E Sodium Salt/(3S,5S)-Atorvastatin Calcium Salt/((3S,5S)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate) Sodium Salt

Atorvastatin EP Impurity E Sodium Salt

1428118-38-0