ChemicalBook > CAS DataBase List > GSK106 (hydrochloride)

GSK106 (hydrochloride)

Product Name: GSK106 (hydrochloride)
CAS No.: 1652591-82-6
Chemical Name: GSK106 (hydrochloride)
Synonyms: GSK106;GSK106 (hydrochloride);(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride
CBNumber: CB93152622
Molecular Formula: C24H28ClN5O
Formula Weight: 437.965
MOL File: 1652591-82-6.mol

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GSK106 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17490
Product name: GSK106 (hydrochloride)
Purity: ≥98%
Packaging: 500μg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17490
Product name: GSK106 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 17490
Product name: GSK106 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 17490
Product name: GSK106 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $494
Updated: 2024/03/01

TRC

Product number: G797390
Product name: (3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanoneHydrochloride
Packaging: 5mg
Price: $235
Updated: 2021/12/16

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GSK106 (hydrochloride) Chemical Properties,Usage,Production

Description

Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199 . It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC₅₀s > 100 μM). See the Structural Genomics Consortium (SGC) website for more information on both GSK484 and GSK106.

Uses

(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride is structurally similar to (3-Amino-1-piperidinyl)[1-methyl-2-(1-methyl-1H-indol-2-yl)-1H-benzimidazol-5-yl]-methanone TFA Salt (G797395) and is suitable to use as a control to identify inhibitors for protein arginine deiminase 4 (PAD4).

GSK106 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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1652591-82-6, GSK106 (hydrochloride)Related Search:

GSK106 (hydrochloride)

(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride

GSK106

1652591-82-6